ID Q6BJ38_DEBHA Unreviewed; 1380 AA.
AC Q6BJ38;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 04-NOV-2008, sequence version 2.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=DEHA2G05456p {ECO:0000313|EMBL:CAG90242.2};
GN OrderedLocusNames=DEHA2G05456g {ECO:0000313|EMBL:CAG90242.2};
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592 {ECO:0000313|EMBL:CAG90242.2, ECO:0000313|Proteomes:UP000000599};
RN [1] {ECO:0000313|EMBL:CAG90242.2, ECO:0000313|Proteomes:UP000000599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC
RC 2968 {ECO:0000313|Proteomes:UP000000599};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
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DR EMBL; CR382139; CAG90242.2; -; Genomic_DNA.
DR RefSeq; XP_461783.2; XM_461783.1.
DR STRING; 284592.Q6BJ38; -.
DR GeneID; 2904660; -.
DR KEGG; dha:DEHA2G05456g; -.
DR VEuPathDB; FungiDB:DEHA2G05456g; -.
DR eggNOG; KOG4305; Eukaryota.
DR HOGENOM; CLU_001251_6_1_1; -.
DR InParanoid; Q6BJ38; -.
DR OMA; FAHVNDI; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000000599; Chromosome G.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000599}.
FT DOMAIN 676..866
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1060..1353
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1380 AA; 156478 MW; 38F9460101CFEB83 CRC64;
MSSSEYPIYS YKRNNAAPNQ HPQYNIPTHL LPQALLDEQR QRQMQGSNSP QRGHIGLNQP
MQGNNSPQRA QMGVNPPMQG NNSPQRAEMG LNQPMQRNDS PQRGQAGVNQ QMPIPIQNVP
KQHVTQGQFM PQQDQGQPFH NQQQPIPQQP MYDSPERRQQ QYPQKVQQNV PNYEGMGNGR
PFNGPRNASL SSLTYGNSGN GNYNKRVNSY SSQESIPQPQ PPYPVSGGYV PNPNNYGQEA
PQIPQQRRTA RKAPPGSLPP IQTNQVLDSS GRRIVSSPSV PQYNSYSYAN HSPISQTHSG
QMNNETRAKS LSSTSGKPYQ QQQQQSRMKP IPQGQASQPS PQQTNHQNHR PGSSGSGSSS
SSHSFSLTSK SRSFTSLSKL SSLSTKKFNS STSLQGSKLD RNPSSATLSS QKTVTTPMPK
KPIVYPAMLS RVARVFKETI ILTINTKDGL EYHDTFTGKM AVDIICKIIR TNDRNLALLI
GRSLDAQKFF RDVTYNHRLR DSIHEVYAFN HIYGEVEFYQ DYNNTNNNSA NNSKHGSITE
GHPQFQQVLL QQLPAHTTNS QPPTPSTPTM SNEGSTYNLN NNKEIPANST SATGVNGVFT
ILTDCYSPTC TRNNLCYSIA CPRRLEQQAR LNLKPQGGLK RAVSRLSLHD KEENKTLWYE
TVPQSILDKL DKREKMRQEL IYEFIYTERD YVKDLEFMTD FYIMPLRNPA NNIIPERERE
VFIRTVFGGV SDLLRLAKNM SEALTRRQLQ QKPVIDTFAD IFVDFVGGFE PFIKYSGNKV
FASFEHERQQ QVNMKYARFL DAIEKKPESR KQDLSSFLIK GIQRPARYQL LISGIIKNTE
PESPDYKSLL KAKEEIEKVL VQINIQTGES TDRHKIMVLH RLLGKQNLET KNHFKLNYSH
RIIYQVTLNR KRDNEKIDLY LFEHALLLIK HKIQNKREQH KIFEKPIYLP LLFVNSGYDI
PTARSIMGNR LDGSLLSDPN LKNKAETSTS YINTSSSSSN KLPINFLGLG SNSVHATLFA
DDMTNQNQVL QQIHQQQKKL IGQNDIFSLS KYETRRFHGN NKINCAVPCY GGKKLLYGTD
SGVWVSTVRS ISATSNEKIC SDPTMVISKV YVTQIEVLVE YSKLLILSDK SLYEFDLSCT
DSLDHNKNTR SGKLILNYVS FFKTGICDGR LLVCAAKHGS THSINIFEPT NPFDHKSSKN
KNKKYDIREI SFSSDPVSIS FLKTKLCVGC TKGFEILSLE KGKKEPILDE ADPSLDFATQ
RESVTPLAIH RLGKNFLLSY SEFSFKINRN GWRTQHDWSV FWEGNPQNIA LFYPYLLSFE
PGFIEVRDLD STNLLRALVG ENIRFLHSNE HEALYACEEN GYDIIVSIDF LNLKPKVTQL
//
