UniProt: Q6C721

Database: UniProt
Entry: Q6C721_YARLI

LinkDB:  Q6C721_YARLI 
Original site:  Q6C721_YARLI

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Ontology (21)   
   GO (21)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (15)   
   InterPro (9)   
   Pfam (3)   
   PROSITE (1)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (41)   

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ID   Q6C721_YARLI            Unreviewed;       738 AA.
AC   Q6C721;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   SubName: Full=YALI0E04444p {ECO:0000313|EMBL:CAG79122.1};
GN   ORFNames=YALI0_E04444g {ECO:0000313|EMBL:CAG79122.1};
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591 {ECO:0000313|EMBL:CAG79122.1, ECO:0000313|Proteomes:UP000001300};
RN   [1] {ECO:0000313|EMBL:CAG79122.1, ECO:0000313|Proteomes:UP000001300}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150 {ECO:0000313|Proteomes:UP000001300};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA   Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA   Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC       {ECO:0000256|ARBA:ARBA00043957}.
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DR   EMBL; CR382131; CAG79122.1; -; Genomic_DNA.
DR   RefSeq; XP_503541.1; XM_503541.1.
DR   AlphaFoldDB; Q6C721; -.
DR   STRING; 284591.Q6C721; -.
DR   EnsemblFungi; CAG79122; CAG79122; YALI0_E04444g.
DR   GeneID; 2912197; -.
DR   KEGG; yli:YALI0E04444g; -.
DR   VEuPathDB; FungiDB:YALI0_E04444g; -.
DR   HOGENOM; CLU_010129_3_2_1; -.
DR   InParanoid; Q6C721; -.
DR   OMA; TMDIIWL; -.
DR   OrthoDB; 2880475at2759; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IBA:GO_Central.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0042134; F:rRNA primary transcript binding; IEA:EnsemblFungi.
DR   GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0071044; P:histone mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0071028; P:nuclear mRNA surveillance; IEA:EnsemblFungi.
DR   GO; GO:0071040; P:nuclear polyadenylation-dependent antisense transcript catabolic process; IBA:GO_Central.
DR   GO; GO:0071039; P:nuclear polyadenylation-dependent CUT catabolic process; IBA:GO_Central.
DR   GO; GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0071036; P:nuclear polyadenylation-dependent snoRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0071037; P:nuclear polyadenylation-dependent snRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IBA:GO_Central.
DR   GO; GO:0000973; P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0034473; P:U1 snRNA 3'-end processing; IEA:EnsemblFungi.
DR   GO; GO:0034475; P:U4 snRNA 3'-end processing; IEA:EnsemblFungi.
DR   GO; GO:0034476; P:U5 snRNA 3'-end processing; IEA:EnsemblFungi.
DR   CDD; cd06147; Rrp6p_like_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR045092; Rrp6-like.
DR   InterPro; IPR049559; Rrp6p-like_exo.
DR   PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR   PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   Pfam; PF08066; PMC2NT; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   3: Inferred from homology;
KW   Exosome {ECO:0000256|ARBA:ARBA00022835};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001300};
KW   rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT   DOMAIN          438..518
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   REGION          598..738
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..631
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        632..667
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..732
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   738 AA;  83512 MW;  69B902D9CAFA78B3 CRC64;
     MEIDSVVRLA QQTAKAARGL ASHDIKFYSS IDDKVADSVK ENASQLIGVV NQLAQKIAPN
     EVGSFPPELD TVNRHWNEFS SVVDDLYEKT DIQLGKLNKK GDKVEIAESK KTGPQTLGEK
     IRVGNAIQSS SEIKGPQWKP QEMWEVDNSR DTPFKPKLTS KPNALEPLED AFELVTEDDR
     RDHYPQPYAK EIMEQPYPDE VYEETEVIPN RPWEAEGEDE YIYVDTEEKL RDMVDHLKTQ
     EEIAIDVEHH SMRTYYGITC LVQVSSREQD YIIDTIALRN LEIFNEVLTD PKIVKVLHGA
     TMDIQWLQRD FGLYIVSLFD TFHAAQALGL KGHSLAFLLQ HYANFVTSKK YQLSDWRIRP
     MSPEQLLYAR ADTHFLLNIY DQLKNALVQK DKIEGVLEKS RQTASQRYEY TGYDPRYYLK
     SFDYEGGINR LISQFHITGP SVSVAKALFL WRDSMARKED ESTGYVMPNY LLVSLANRMP
     QTPEAVFSVS KSLPLLVRKN VEEILDVIKD SKDEHVEVEQ VEEEPVLAAE SIEGAEFSEI
     AEVIFLAAQD GQSDITGKFD SSKSSIVHVK ETALGPLGVS KIDKHMMVLA VPVAPLSVDS
     TESDSEVQNA EEEVKVEQDA AADDESDYSE DEHEHANDII IAKSNKKYTA DKEAKKGVAK
     EKSEEFTPFD YSAGASILKS DDQKAAEKKA AMTARKQKAK EKKQFNPYEI KEDAKGASKR
     RGPKDGGARS VQYKKRRT
//

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