ID Q6CM67_KLULA Unreviewed; 806 AA.
AC Q6CM67;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=KLLA0E22551p {ECO:0000313|EMBL:CAH00059.1};
GN ORFNames=KLLA0_E22551g {ECO:0000313|EMBL:CAH00059.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH00059.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH00059.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
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DR EMBL; CR382125; CAH00059.1; -; Genomic_DNA.
DR RefSeq; XP_454972.1; XM_454972.1.
DR AlphaFoldDB; Q6CM67; -.
DR STRING; 284590.Q6CM67; -.
DR PaxDb; 284590-Q6CM67; -.
DR GeneID; 2894413; -.
DR KEGG; kla:KLLA0_E22551g; -.
DR eggNOG; KOG0941; Eukaryota.
DR HOGENOM; CLU_002173_5_1_1; -.
DR InParanoid; Q6CM67; -.
DR OMA; YGNDWHI; -.
DR Proteomes; UP000000598; Chromosome E.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 466..806
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 774
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 806 AA; 93954 MW; 91D0D1A5F2E91D82 CRC64;
MFKFNPLHIV GREKIKIRYQ SSDRLDCEDP PKFRETRCRC CGTLLRHPID AVKFKCTICE
VTVVLRQTAN SRDTEGKILP DLEQLSNIVG QCLESYKKDQ TGDETPAKEL NSYFIPVEKY
IVQKFGTAEA LNQLFKPTVK DQIINYEKAV TFYNLIGSLP TKRPIYLILR VFNEVLKRPK
ILMDKWEHYL FIFFILEVPS LRQCINNSTT ISRTPKIKTL SYEILKRCIG YLGSMNSKVS
VKYKNHLVRL HPLKFQKQWE ILNLYLSYQF QKIGPGPPHS PRGLSGTLLT ESSPVDETKD
GTVSYLFHPG RQKIPLESRF RIEKYGLDWH IRTVCQLMNI YFQAHCEQPK CDISVFYNMI
IDFIDYKRDF MMWHKMNREQ WRTLDDLSMT QLHETHYTAL CQYPFLMSLG VKIAIMEFET
GKMMEHNAEQ AFLKALDSRK LYDVHFRIKV RRSHVTQDSL TSIQRHPHDL KKSLRVEFSN
EPGIDAGGLK KEWFLLLTRE LFHPNHGLFQ YVEESRLSWF AYGNTGLKLH GENNNELYYL
FGVVLGLAIY NSTILDLHFA RAMYKKLCNE RITFEDYEEL YPETARNLKK MLSYSELDFS
DIFGLSFETT YYDVASGINV TKPLCDGGES IPVTSENKTE FVERWVNFYM NEGVSSSFSA
FQSGFTRVIG DGLAFPMFKS CEVERLICGS IEQDMDFEQL RAVTKYQGGF HNQTPVVEWL
WEILPQLSHE QQRQFLHFVT GSDRVPVTGL ATLPFKVTRT TSGSHDQLPT AHTCFNELCL
YEYESRDTLL LRLVTALEMY EGYGFK
//
