ID Q6CSG2_KLULA Unreviewed; 744 AA.
AC Q6CSG2;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=KLLA0D01309p {ECO:0000313|EMBL:CAH00223.1};
GN ORFNames=KLLA0_D01309g {ECO:0000313|EMBL:CAH00223.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH00223.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH00223.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; CR382124; CAH00223.1; -; Genomic_DNA.
DR RefSeq; XP_453127.1; XM_453127.1.
DR AlphaFoldDB; Q6CSG2; -.
DR STRING; 284590.Q6CSG2; -.
DR PaxDb; 284590-Q6CSG2; -.
DR GeneID; 2893367; -.
DR KEGG; kla:KLLA0_D01309g; -.
DR eggNOG; KOG2206; Eukaryota.
DR HOGENOM; CLU_010129_3_2_1; -.
DR InParanoid; Q6CSG2; -.
DR OMA; TMDIIWL; -.
DR Proteomes; UP000000598; Chromosome D.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 435..515
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 100..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..744
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 85118 MW; D678F729CD6500F4 CRC64;
MSSEDKDTLL SSLVQTVRSS SALAAQDIDF YKSLDSNINA SLEDTSTNIL SLINDLLLSI
DPNNDVIQQG KDSFVDSWKS ISNIMDNLFE KSDHALDNIR AGNGGNAGGP SLKYLNDDDR
SNNKPSKRIE KPQLSFKTPV DNTELHPFKP LLEYKPHSLQ PFEISLKMVP EEESIPSHYP
HPYEYEIDHQ KYNDSILVAT EPIPSKDWDE TEAIWVDTVE GLNKMKDELS KATELAIDLE
HHDYRSYYGI VCLMQISDRE HDWIVDTIAL REELYILNDI FTDPNVTKVL HGAFMDIIWL
QRDLGLYIVG LFDTYHASRM LGFPKHSLAY LLERFANFKT SKKYQLADWR IRPLTKPMLA
YARADTHFLL NIFDKLRNSL LEQNKMSDVL HESRKVAKRR FEYSSFRPKV PSSAVFSPIE
KDEPWKNIMF QYNIPASKEL LLRRLYEWRD TIARRDDESP RYVMPNQLLV SLVAGAPTEP
INVLSVSSYV SEHLRTNSKV IANLIKRTLE DLKGNSNSSA IPLLESAESN GTDLANIITT
SQIKSIQNIF HSLASEINSQ KLNNEQNSEK SVLFNGISNL DVNTAVRYTP KTRTLIPQHE
LLKRQHEITR TLEQEYTDRQ AQSIVLPSNE DEAPTQVSND ENRNEVITSD PSQEEIEENK
DEVITLRKRQ SQSNNKRKTI SPPASHEIMD YAAGSDLLNS TKNNTNSQKH KKRRFDPYSV
EHVGPQPIKK KSKPAKGKNV SFKR
//
