ID CMR1_KLULA Reviewed; 512 AA.
AC Q6CT00;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 109.
DE RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN OrderedLocusNames=KLLA0C16533g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR EMBL; CR382123; CAH01790.1; -; Genomic_DNA.
DR RefSeq; XP_452939.1; XM_452939.1.
DR AlphaFoldDB; Q6CT00; -.
DR SMR; Q6CT00; -.
DR STRING; 284590.Q6CT00; -.
DR PaxDb; 284590-Q6CT00; -.
DR GeneID; 2892075; -.
DR KEGG; kla:KLLA0_C16533g; -.
DR eggNOG; KOG4328; Eukaryota.
DR HOGENOM; CLU_017019_1_1_1; -.
DR InParanoid; Q6CT00; -.
DR OMA; DTVVRHN; -.
DR Proteomes; UP000000598; Chromosome C.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14773; UNCHARACTERIZED; 1.
DR PANTHER; PTHR14773:SF0; WD REPEAT-CONTAINING PROTEIN 76; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..512
FT /note="DNA damage-binding protein CMR1"
FT /id="PRO_0000351109"
FT REPEAT 189..230
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 241..281
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 289..329
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 333..373
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 390..429
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 442..481
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 482..512
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REGION 32..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 58022 MW; 14A55614E3871785 CRC64;
MGELTEFQKK RLENIKRNND LLKKLNLNNV SSQIKREAGV EDEHLDRKRK KKAGSAKKAV
KKEPKPAAIP TRRSRRLRGE NVDGNGIPNV NDNQLLKMGQ SDSTPELEAI DELKNTALSG
DVKLSDLIKS ENEEELLDKF KSFANKNFSS GDFFKELQQQ QVPTPEIKQL QEDFDLKLYD
IFQPNEIKLT AERISATFFH PSVDKKLVIC GDTAGNVGLW NVRETQPEDE LEEPDITKVK
LFTKNVGRID TYATDSSRLL AASYDGYLRS INLQDMNSEE ILVLKNEYDD PLGISDFQFN
YNDPNVLFMT TLSGEFTTFD VRTKPTEINL KRLSDKKIGS FSINPKRPYE IATGSLDRTL
KIWDTRKIVN KPEWSQYEDF ASHEIVATYD SRLSVSAVSY SPMDETLVCN GYDDTIRLFD
VSGTLPEDLQ PKLTLKHNCQ TGRWTSILKA RFKLNMDVFA IANMKRAIDI YTSSGVQLAH
LPTATVPAVI SWHPTQNWVV GGNSSGKAFL FT
//
