ID Q6CVZ2_KLULA Unreviewed; 1729 AA.
AC Q6CVZ2;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 113.
DE SubName: Full=KLLA0B08239p {ECO:0000313|EMBL:CAH02290.1};
GN ORFNames=KLLA0_B08239g {ECO:0000313|EMBL:CAH02290.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH02290.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH02290.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR382122; CAH02290.1; -; Genomic_DNA.
DR RefSeq; XP_451897.1; XM_451897.1.
DR STRING; 284590.Q6CVZ2; -.
DR PaxDb; 284590-Q6CVZ2; -.
DR GeneID; 2897157; -.
DR KEGG; kla:KLLA0_B08239g; -.
DR eggNOG; KOG1070; Eukaryota.
DR HOGENOM; CLU_000845_0_0_1; -.
DR InParanoid; Q6CVZ2; -.
DR OMA; GQYLRAY; -.
DR Proteomes; UP000000598; Chromosome B.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd00164; S1_like; 1.
DR CDD; cd05702; S1_Rrp5_repeat_hs11_sc8; 1.
DR CDD; cd05703; S1_Rrp5_repeat_hs12_sc9; 1.
DR CDD; cd05693; S1_Rrp5_repeat_hs1_sc1; 1.
DR CDD; cd05698; S1_Rrp5_repeat_hs6_sc5; 1.
DR CDD; cd05706; S1_Rrp5_repeat_sc10; 1.
DR CDD; cd05708; S1_Rrp5_repeat_sc12; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 9.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR045209; Rrp5.
DR InterPro; IPR048058; Rrp5_S1_rpt_hs11_sc8.
DR InterPro; IPR048059; Rrp5_S1_rpt_hs1_sc1.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR23270; PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5; 1.
DR PANTHER; PTHR23270:SF10; PROTEIN RRP5 HOMOLOG; 1.
DR Pfam; PF00575; S1; 3.
DR SMART; SM00386; HAT; 5.
DR SMART; SM00316; S1; 13.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 10.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50126; S1; 10.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 117..227
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 496..566
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 593..662
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 682..755
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 780..849
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 879..955
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 986..1058
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1071..1142
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1160..1228
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1248..1319
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1325..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1419..1440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..181
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1331..1353
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1729 AA; 192910 MW; 5524B9A9596446D7 CRC64;
MVAPQSKRKR DDESPLVRQD ATEAPAKSAL SKSEEISFPR GGSSALSPLE VKQVGNEVVA
DVLFGKDESA TGAEGPTKKK KKNAKNNFDQ ITTGDDEEKE DKTDLIEHFG MKQMTKGTIV
LGQIQSISKH ELKISLVDGL HGYVSLTDIS EQMTKILENL DESMESDDEK NEDSEYDSSD
DESDITTPKE LPDLNKYFKI GQWLRCMVQN NSALESNKNK KLDLSIEPSV VNVFEDDDLA
KNCPLQCSLK SIEDHGAILD IGIENLTGFI SKKDIPEFSS LLPGMVFLAT VTKRSGRTVN
VNLDLASKNT KVEKISSIDA IVPGQSIDFL PQTITNHGVI GKAFGLITAF LPLPHSNFFT
VEDLKHHYSI GDLVNARILA TTIVKSGDKV AVVSTQPHII SLHPKLQETE ALESFPVGYI
FDSCTVKGRD SQFFYVSINN EQVGQIHLSK AGETEPTGTV KARILGYNNV DKLYTLTSDP
ALLDVKYLRS SDIPAGEVLS ACEIVTVSGK GIELKIFNDQ FKAFVPPLHI SDTRLVYPER
KFKIGSKVKG RVLNVDSVGR VTVTLKKSIV NADEESVTLV CKNDDIQTVE SQELKTIGTV
EIFKPNGCVI SFFNNIKAFV PNKEISEAFV KKPQEHLRLG QSVLVKILNH DFERNRIIAS
CKISAESSSK QKSAIESLVV GKSIIDAIVI EKTKDSVIVE SKDSGLRGVI YTGHLSDDRI
EQNRASQKKL KINSEVRGLV LDKDIRTHVF NMSCKKSLIK DAEDGTLPLS FSDIKNKDKT
EPMHGYVKSV SDRGVFVAFN GKFVGLVLPS YAAETRDIDI HKKYYINQSV TVYLLRTDEE
HERFLLTILK QKTDVKKINS SVINPVDKSI KDLSDFTIGK VTKATITSVK KNQLNVTLAD
NVHGRISISE VFDSFEDIKE QKAPLSVYKK NDSLSVRVIG FHDIKSRKFL PISHTTSKSH
LVELSAKPSS LTSPVSEKKL KDFTPEQTTF GFINNYSNDT AWLTITPTVK AKLPIFEISD
EGHDFSLPIE EKYPIGTAVR VTVKSIDTEH DSLVVSARSH AISSISEIKE GDVLPARVIS
VQDTYVLLSL GKDVTGVSFI TDALDDYSLS LKDVYDSKKK NIVSATVLNV DIDNNKINLS
LRSSSPKDRT IISSSELKRG DIVRGFVKSI TDKGVFISLS SVLQAFVPVS KLTDAFIKDW
KKFFRRGQSV VGKVVNCDND DRVLLTLRES EVNGQLNVLK SYSDINVGDI FQGSVKNVTD
FGVFVKLDGT VNVTGLAHKS EVADAKIDNL QNLFGEGDKV KAIVLKTNPE KKQISLGLKA
SYFTNEKPET VEEGNEEEEE LEGVDDLDID MEDGQKESDA SDKDEDKDED QDEIMDDAQF
GHSDSEAEDT TRPKNSAPVS TDGLSLSTGF DWTASILDQA QDEEESSEED EDFIKSRKQK
KKKTQIVQDK TVDINTRIPE SVGDFERLIM GNPNSSVVWM NYMAFHLQLS EVEKAREIVE
RALKTINFRE ESEKLNIWIA SLNLENTFGT EETVEDVFTK ACQYMDSFTM HMKLLSIYQM
SEKIEKAKEL FKITAKKFGS EKVSIWVAWG EFLIDNNLID EAHEVLGNSL KSLPTRNHIE
VVRKFAQLEF SKGDPEQGRS LFEGLLADAP KRVDLWNVYI DQEIKHGEKS KAEDLFERVI
TKKITRKQAK FFFNKWLQFE EQKDDQKLVD YVKAKAAEYV KKNKSADTE
//
