ID Q6CWU3_KLULA Unreviewed; 136 AA.
AC Q6CWU3;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 04-NOV-2008, sequence version 2.
DT 24-JAN-2024, entry version 106.
DE SubName: Full=KLLA0B01474p {ECO:0000313|EMBL:CAH01989.2};
GN ORFNames=KLLA0_B01474g {ECO:0000313|EMBL:CAH01989.2};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH01989.2, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH01989.2, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [2] {ECO:0007829|PDB:3J80, ECO:0007829|PDB:3J81}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.75 ANGSTROMS).
RX PubMed=25417110; DOI=10.1016/j.cell.2014.10.001;
RA Hussain T., Llacer J.L., Fernandez I.S., Munoz A., Martin-Marcos P.,
RA Savva C.G., Lorsch J.R., Hinnebusch A.G., Ramakrishnan V.;
RT "Structural changes enable start codon recognition by the eukaryotic
RT translation initiation complex.";
RL Cell 159:597-607(2014).
RN [3] {ECO:0007829|PDB:3JAM, ECO:0007829|PDB:3JAP}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.46 ANGSTROMS).
RX PubMed=26212456; DOI=10.1016/j.molcel.2015.06.033;
RA Llacer J.L., Hussain T., Marler L., Aitken C.E., Thakur A., Lorsch J.R.,
RA Hinnebusch A.G., Ramakrishnan V.;
RT "Conformational differences between open and closed states of the
RT eukaryotic translation initiation complex.";
RL Mol. Cell 59:399-412(2015).
RN [4] {ECO:0007829|PDB:5IT7, ECO:0007829|PDB:5IT9}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS) OF 2-130.
RX PubMed=27159451; DOI=10.7554/eLife.13567;
RA Murray J., Savva C.G., Shin B.S., Dever T.E., Ramakrishnan V.,
RA Fernandez I.S.;
RT "Structural characterization of ribosome recruitment and translocation by
RT type IV IRES. .";
RL Elife 5:e13567-e13567(2016).
RN [5] {ECO:0007829|PDB:6FYX, ECO:0007829|PDB:6FYY}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.05 ANGSTROMS).
RX PubMed=30475211; DOI=10.7554/eLife.39273;
RA Llacer J.L., Hussain T., Saini A.K., Nanda J.S., Kaur S., Gordiyenko Y.,
RA Kumar R., Hinnebusch A.G., Lorsch J.R., Ramakrishnan V.;
RT "Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal
RT subunit to promote start-codon recognition.";
RL Elife 7:e39273-e39273(2018).
RN [6] {ECO:0007829|PDB:6UZ7}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS).
RX PubMed=31900355; DOI=10.1073/pnas.1916436117;
RA Huang B.Y., Fernandez I.S.;
RT "Long-range interdomain communications in eIF5B regulate GTP hydrolysis and
RT translation initiation.";
RL Proc. Natl. Acad. Sci. U.S.A. 117:1429-1437(2020).
RN [7] {ECO:0007829|PDB:6GSM, ECO:0007829|PDB:6GSN}
RP STRUCTURE BY ELECTRON MICROSCOPY (5.15 ANGSTROMS) OF 2-126.
RX PubMed=34648019; DOI=10.1093/nar/gkab908;
RA Llacer J.L., Hussain T., Dong J., Villamayor L., Gordiyenko Y.,
RA Hinnebusch A.G.;
RT "Large-scale movement of eIF3 domains during translation initiation
RT modulate start codon selection.";
RL Nucleic Acids Res. 49:11491-11511(2021).
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS17 family.
CC {ECO:0000256|ARBA:ARBA00010444}.
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DR EMBL; CR382122; CAH01989.2; -; Genomic_DNA.
DR RefSeq; XP_451596.2; XM_451596.2.
DR PDB; 3J80; EM; 3.75 A; R=1-136.
DR PDB; 3J81; EM; 4.00 A; R=1-136.
DR PDB; 3JAM; EM; 3.46 A; R=1-136.
DR PDB; 3JAP; EM; 4.90 A; R=1-136.
DR PDB; 5IT7; EM; 3.60 A; R=2-130.
DR PDB; 5IT9; EM; 3.80 A; R=2-130.
DR PDB; 6FYX; EM; 3.05 A; R=1-136.
DR PDB; 6FYY; EM; 3.05 A; R=1-136.
DR PDB; 6GSM; EM; 5.20 A; R=2-126.
DR PDB; 6GSN; EM; 5.75 A; R=2-131.
DR PDB; 6UZ7; EM; 3.60 A; R=1-136.
DR PDBsum; 3J80; -.
DR PDBsum; 3J81; -.
DR PDBsum; 3JAM; -.
DR PDBsum; 3JAP; -.
DR PDBsum; 3JAQ; -.
DR PDBsum; 5IT7; -.
DR PDBsum; 5IT9; -.
DR PDBsum; 6FYX; -.
DR PDBsum; 6FYY; -.
DR PDBsum; 6GSM; -.
DR PDBsum; 6GSN; -.
DR PDBsum; 6UZ7; -.
DR AlphaFoldDB; Q6CWU3; -.
DR EMDB; EMD-0057; -.
DR EMDB; EMD-0058; -.
DR EMDB; EMD-20952; -.
DR EMDB; EMD-4327; -.
DR EMDB; EMD-4328; -.
DR EMDB; EMD-8123; -.
DR SMR; Q6CWU3; -.
DR STRING; 284590.Q6CWU3; -.
DR PaxDb; 284590-Q6CWU3; -.
DR GeneID; 2897012; -.
DR KEGG; kla:KLLA0_B01474g; -.
DR eggNOG; KOG0187; Eukaryota.
DR HOGENOM; CLU_112958_0_1_1; -.
DR InParanoid; Q6CWU3; -.
DR Proteomes; UP000000598; Chromosome B.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 1.10.60.20; Ribosomal protein S17e-like; 1.
DR HAMAP; MF_00511; Ribosomal_S17e; 1.
DR InterPro; IPR001210; Ribosomal_eS17.
DR InterPro; IPR018273; Ribosomal_eS17_CS.
DR InterPro; IPR036401; Ribosomal_eS17_sf.
DR PANTHER; PTHR10732; 40S RIBOSOMAL PROTEIN S17; 1.
DR PANTHER; PTHR10732:SF0; 40S RIBOSOMAL PROTEIN S17; 1.
DR Pfam; PF00833; Ribosomal_S17e; 1.
DR SUPFAM; SSF116820; Rps17e-like; 1.
DR PROSITE; PS00712; RIBOSOMAL_S17E; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3J80, ECO:0007829|PDB:3J81};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980}.
SQ SEQUENCE 136 AA; 15691 MW; E5C7B26B9DE15ACF CRC64;
MGRVRTKTVK RASKALIEKY YPKLTMDFQT NKRLCDEIAT IQSKRLRNKI AGYTTHLMKR
IQKGPVRGIS FKLQEEERER KDQYVPDVSA LDLSHSNDVL NVDTQTAELV NSLGLKLPLS
VSSVSAVRDR RFRKRN
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