ID Q6CXB0_KLULA Unreviewed; 1319 AA.
AC Q6CXB0;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 125.
DE SubName: Full=KLLA0A09823p {ECO:0000313|EMBL:CAH03017.1};
GN ORFNames=KLLA0_A09823g {ECO:0000313|EMBL:CAH03017.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH03017.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH03017.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
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DR EMBL; CR382121; CAH03017.1; -; Genomic_DNA.
DR RefSeq; XP_451429.1; XM_451429.1.
DR STRING; 284590.Q6CXB0; -.
DR PaxDb; 284590-Q6CXB0; -.
DR GeneID; 2896382; -.
DR KEGG; kla:KLLA0_A09823g; -.
DR eggNOG; KOG0732; Eukaryota.
DR HOGENOM; CLU_000536_6_1_1; -.
DR InParanoid; Q6CXB0; -.
DR OMA; NAQMGIE; -.
DR Proteomes; UP000000598; Chromosome A.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd05491; Bromo_TBP7_like; 1.
DR CDD; cd19517; RecA-like_Yta7-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR045199; ATAD2-like.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23069; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23069:SF0; TAT-BINDING HOMOLOG 7; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000000598}.
FT DOMAIN 1025..1067
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1198..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..116
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..170
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1257
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1319 AA; 148989 MW; 2C5CA74FE58D834B CRC64;
MTLHSKSGDD ESGTHTEFYD DNGIAHTTPR LLKKVNYAEI ENGYDYIEES DTNSGGTAAV
GANYSDTGTG RRRGRRPGQR NKRVRDDDDD DDVSFHEEDV DDDDDDDDDV DDGDEYIDPA
DDRKRIARRR DKNFIVKDDE DGSDGNEDYS IKEEDLDEDE DDGDEDEEDD DGTVRRGRRP
KRSAARSTRR EQPPRKLRPH RTRSSRVVDD DEDDDDTVGS GRHRSASART REALTLEDEI
RELQEDSPIR EKRSLRERTK PVNYTIPPPL SENQIGAMEA TSVPGIPPGT LPYQSSVYQS
PRGKRGLHSG QSFGPIRRLF PTGGPFGGND VTAIFGKNVQ FYNSNPNALN EQSNKFLDSD
SSDDEILALG MKPKPKDPSK QKKKKKPEIA DLDPLGVDMN INFDDVGGLD NYIDQLKEMV
ALPLLYPELY QNFNITPPRG VLFHGPPGTG KTLMARALAA SCSNEKRKIT FFMRKGADIL
SKWVGEAERQ LRLLFEEAKK HQPAIIFFDE IDGLAPVRSS KQEQIHASIV STMLALMDGM
DNRGQIIIIG ATNRPDAVDP ALRRPGRFDR EFYFPLPDLK ARDKILHIHT KKWNPPISDQ
FISKLASLTK GYGGADLRAL CTEASLISIQ RKFPQIYKSE EKLKIDPKSV RVKARDFMLA
LEKIVPSSAR ATGSTAQPLP KYVEPLLAQQ FINVKDQLNL LLPKQSTKLK SGSSIIQYYL
ENEDLEDSDD EEGTGFDKHE FLKLIKKSRV CKPKLLITGP PGNGLQYIAS ATLHFLEDYN
IQMLDIPTLV SESSRTMEAA LVQTFAEAKK RQPSVICIPN LELWLQACPQ SCLITLTTLF
RSLQSNENVV LLAIADGLSR AEIEDGPLAM FSFGPNIVNI NEPSPHQRFM YFKTVADLIK
MKPTQYIESR KRKKPLPKLP VVETSQEIDE NGRLLTEEEK LRLELKKFQH QDMKLKNTLK
IKLSGLMDLF KNRYKRFRKP PIDDTFLIHL FEPETFAANQ GWQPAYVKDG DMILEVATGR
KFYNMDLDII EERLWNGYYS EPKQFLKDIE LIYLDATTSA DRERVIKASE MFANAQVGIE
DISQPEFVAE CKATRQRELL RQELFIKEKS ERVDKEQQIL LQNNPTQTDS IATVELTTAS
GNQVQSQAQL DAGTLDLGET SQVEPFTTQP VNFGTNDADL AKTDTVQDYS ESRLTNAENG
FAQTSHNNSH LTVDTEDATN KEQEKQPPSV TEAEVEPEAQ SEPEPESEPE SELEPEPEFV
YDESRALSLI SALEKNTQNF TVEKLEEVYA SIANVIWNNR LSWDKTDALD QLEGLIKTL
//
