ID Q6DDN0_XENLA Unreviewed; 358 AA.
AC Q6DDN0;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=MGC82772 protein {ECO:0000313|EMBL:AAH77517.1};
DE SubName: Full=Mohawk homeobox S homeolog {ECO:0000313|RefSeq:NP_001086829.1};
GN Name=mkx.S {ECO:0000313|RefSeq:NP_001086829.1,
GN ECO:0000313|Xenbase:XB-GENE-866492};
GN Synonyms=MGC82772 {ECO:0000313|EMBL:AAH77517.1}, mkx
GN {ECO:0000313|RefSeq:NP_001086829.1,
GN ECO:0000313|Xenbase:XB-GENE-866492}, mwk
GN {ECO:0000313|RefSeq:NP_001086829.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH77517.1};
RN [1] {ECO:0000313|RefSeq:NP_001086829.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH77517.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH77517.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001086829.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC {ECO:0000256|ARBA:ARBA00008446}.
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DR EMBL; BC077517; AAH77517.1; -; mRNA.
DR RefSeq; NP_001086829.1; NM_001093360.1.
DR DNASU; 446664; -.
DR GeneID; 446664; -.
DR KEGG; xla:446664; -.
DR AGR; Xenbase:XB-GENE-866492; -.
DR CTD; 446664; -.
DR Xenbase; XB-GENE-866492; mkx.S.
DR OrthoDB; 3180467at2759; -.
DR Proteomes; UP000186698; Chromosome 6S.
DR Bgee; 446664; Expressed in blastula and 7 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0003002; P:regionalization; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR PANTHER; PTHR11211:SF3; HOMEOBOX PROTEIN MOHAWK; 1.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 66..128
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 68..129
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 52..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 40261 MW; 84FF919E6D0E6C47 CRC64;
MNAIVFNKLS GQVLFEESAN DRERGVRPYL GVMESPNPDV GLQDGVSIKD NASLRHRRPG
SSRGSGKVRH KRQALQDMAR PLKQWLYKHR DNPYPTKTEK ILLALGSQMT LVQVSNWFAN
ARRRLKNTVR QPDLSWALRI KLYNKYVQGN AERLSVSSED SCSEDGEHVP RSHNNEEAYD
KPMHHTVITK ESSVIKSGVR AESSASEDYV SPPKYKSSLL HRYLNDSLRH VMASNAAMRE
KTRQRNHSGS FSSNEFEEEL VSPSSSETEG NFVYRTDMLE SAANKCQSIP LKNTSSSGTE
GRAVFTEGGL CSQIWRIRPA AILSCAGQGA TYTKHVQLIK KEPAKMKRTG GRLMQPWP
//
