ID Q6DEK7_DANRE Unreviewed; 556 AA.
AC Q6DEK7;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Zgc:100868 {ECO:0000313|EMBL:AAH77104.1};
GN Name=zgc:100868 {ECO:0000313|EMBL:AAH77104.1,
GN ECO:0000313|RefSeq:NP_001003526.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040801-33};
GN Synonyms=fc74e04 {ECO:0000313|RefSeq:NP_001003526.1}, im:7038378
GN {ECO:0000313|RefSeq:NP_001003526.1}, wu:fc74e04
GN {ECO:0000313|RefSeq:NP_001003526.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH77104.1};
RN [1] {ECO:0000313|EMBL:AAH77104.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Singapore local strain {ECO:0000313|EMBL:AAH77104.1};
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH77104.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:NP_001003526.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001003526.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [4] {ECO:0000313|RefSeq:NP_001003526.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001003526.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [5] {ECO:0000313|RefSeq:NP_001003526.1}
RP IDENTIFICATION.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001003526.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC077104; AAH77104.1; -; mRNA.
DR RefSeq; NP_001003526.1; NM_001003526.1.
DR MEROPS; S01.159; -.
DR GeneID; 554458; -.
DR KEGG; dre:554458; -.
DR AGR; ZFIN:ZDB-GENE-040801-33; -.
DR ZFIN; ZDB-GENE-040801-33; zgc:100868.
DR OrthoDB; 4261669at2759; -.
DR PhylomeDB; Q6DEK7; -.
DR Proteomes; UP000000437; Chromosome 3.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24253:SF144; BRAIN-SPECIFIC SERINE PROTEASE 4; 1.
DR PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR Pfam; PF00089; Trypsin; 2.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
DR PROSITE; PS50240; TRYPSIN_DOM; 2.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 1..167
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 226..498
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 506..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 57925 MW; AF691D01DC7E7B82 CRC64;
MSSAVSNIIK HPNYNSDTED NDITLLQLAS TVSFSNYIRP ICLAASDSTF FNGTLVWITG
WGNTATGVSL PSPGTLQEVQ VPIVGNRKCN CLYGVSKITD NMVCAGLLQG GKDSCQGDSG
GPMVSKQGSV WIQSGIVSFG TGCAQPNFPG VYTRVSKYQS WIQQRITTTQ PGFVMYNSNG
TDGDLSVNCP GLPTIPPTTA STTQTTTMST TTVAPVVCGS AKLNSGAGGN SLLASPGMWP
WIASVQFNGS HVCGGALIAE QFVMTSASCF PNSTNATGWT VVLGRLNQNS SNPNEVSIKV
ANFSMSNNSG DNVAVLQLAV TPNFTNYIQP ICVDLGGNNV DANTQCWAAG WGSGAGGVNQ
TLQQYQTSIV SCGNSSSNNS ICTTAFDLQQ GVQGGPLMCL VGQSWIHIAV LTISNSNSNS
SISNSTLNNS TLNNCTVNNS TVNNCTVNNS TVNNSTANNS TSSTGSKGAD LYFPVRAQGV
QIFTKTSSFS TFLTAVISSF PQKATNTTSA STSAPSASTS NTTQSNGSPA SFSSCYTVSV
FFSSLLTLQI FHKSIF
//
