ID Q6DIV9_XENTR Unreviewed; 234 AA.
AC Q6DIV9; F6V456; F7AW91;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE RecName: Full=Pentraxin family member {ECO:0000256|RuleBase:RU362112};
GN Name=crp {ECO:0000313|EMBL:AAH75426.1,
GN ECO:0000313|RefSeq:NP_001006708.1,
GN ECO:0000313|Xenbase:XB-GENE-5780408};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH75426.1};
RN [1] {ECO:0000313|RefSeq:NP_001006708.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH75426.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:AAH75426.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001006708.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|RuleBase:RU362112};
CC Note=Binds 2 calcium ions per subunit. {ECO:0000256|RuleBase:RU362112};
CC -!- SUBUNIT: Homopentamer. Pentaxin (or pentraxin) have a discoid
CC arrangement of 5 non-covalently bound subunits.
CC {ECO:0000256|RuleBase:RU362112}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362112}.
CC -!- SIMILARITY: Belongs to the pentraxin family.
CC {ECO:0000256|RuleBase:RU362112}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR EMBL; BC075426; AAH75426.1; -; mRNA.
DR RefSeq; NP_001006708.1; NM_001006707.1.
DR STRING; 8364.ENSXETP00000000072; -.
DR PaxDb; 8364-ENSXETP00000053964; -.
DR DNASU; 448345; -.
DR GeneID; 448345; -.
DR KEGG; xtr:448345; -.
DR AGR; Xenbase:XB-GENE-5780408; -.
DR CTD; 1401; -.
DR Xenbase; XB-GENE-5780408; crp.
DR eggNOG; ENOG502S26Y; Eukaryota.
DR HOGENOM; CLU_032051_2_0_1; -.
DR OMA; NINYVEM; -.
DR OrthoDB; 4219275at2759; -.
DR PhylomeDB; Q6DIV9; -.
DR TreeFam; TF330208; -.
DR Proteomes; UP000008143; Chromosome 4.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR45869; C-REACTIVE PROTEIN-RELATED; 1.
DR PANTHER; PTHR45869:SF2; PENTAXIN; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|RuleBase:RU362112};
KW Metal-binding {ECO:0000256|RuleBase:RU362112};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|RuleBase:RU362112, ECO:0000313|RefSeq:NP_001006708.1}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU362112"
FT CHAIN 19..234
FT /note="Pentraxin family member"
FT /evidence="ECO:0000256|RuleBase:RU362112,
FT ECO:0000313|RefSeq:NP_001006708.1"
FT /id="PRO_5033206014"
SQ SEQUENCE 234 AA; 25736 MW; BC1E974895F014F7 CRC64;
MAIAIIGALL FIISTGLCAT EGNQDLQGKS LSFEKQTFSN YAILHPKKPL NLDAFTLCLR
VSAEPPGNRD MILFSYFGKG ADQLNLWRER DGRFSLYLAS SVEGVFFSLP QISTFGTQLC
VTWESSSGTT AFWVDGKMSV RKTYRQHHKV PGGGTVILGQ DQDLQGGGFD ASQSFVGEVT
NVNLWDYVLP CEFTSEAFAL GGNVINWGEV QCKIVGEVKM YESGGKYIEE QIVE
//
