ID Q6DNE1_9CYAN Unreviewed; 1956 AA.
AC Q6DNE1;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=CurL {ECO:0000313|EMBL:AAT70107.1};
GN Name=curL {ECO:0000313|EMBL:AAT70107.1};
OS Lyngbya majuscula.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Oscillatoriaceae; Lyngbya.
OX NCBI_TaxID=158786 {ECO:0000313|EMBL:AAT70107.1};
RN [1] {ECO:0000313|EMBL:AAT70107.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=19L {ECO:0000313|EMBL:AAT70107.1};
RX PubMed=15332855; DOI=10.1021/np0499261;
RA Chang Z., Sitachitta N., Rossi J.V., Roberts M.A., Flatt P.M., Jia J.,
RA Sherman D.H., Gerwick W.H.;
RT "Biosynthetic pathway and gene cluster analysis of curacin A, an
RT antitubulin natural product from the tropical marine cyanobacterium Lyngbya
RT majuscula.";
RL J. Nat. Prod. 67:1356-1367(2004).
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DR EMBL; AY652953; AAT70107.1; -; Genomic_DNA.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 6.10.250.3430; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR049490; C883_1060-like_KR_N.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020803; PKS_MeTfrase.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF21394; Beta-ketacyl_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00828; PKS_MT; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 38..462
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1827..1905
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1956 AA; 215948 MW; CA71015F97E0676C CRC64;
MNLKQEQEKE QSLSALQRAL IALKDARSKL EKYETQSKEP IAIIGMSCRF PGGVDSPESF
WQLLNDGVDA ISEVPSNRWN INNYYDPDPD ATGKISTRDG GFLSQIDGFD APFFCISPRE
VQSLDPQQRL LLEVSWEAIE RANIVPDQLF NSLTGVFIGI GSSDYLNQLA TSEVPQAYWG
TGNAPSAATG RLSYILGLTG PNLAVETACS SSLVSLHLAC QSLRQQECNL ALAGGVNLLL
SPETSIIFSQ AKMLSPDGRC KTFDASANGY VRGEGCGVIV LKRLSDAVAN GDNVLAVIRG
TAINQDGASG GLTVPNGPSQ VAVIRKALSN GGVDPASVSY IEAHGTGTSL GDPIEVGAIG
TVFGKTHSQE QPLIVGTAKT NIGHLEVAAG IAGLMKVVLQ LQHQQIAPSL HFKQPNPYIN
WSQLPVQVST QLTPWQTNGK SRIAGVSSFG FSGTNAHVVI EEAPKEGNSL SATVEENGNS
TVKEDTLERA VYLLTLSAKT QAALDDLVNS YQNYLKNYPE LRIADICYTA NTCRSHFNNR
LAVVASNQQE LVEKLRQHQQ GEEVTGIYSI ELPNNSTAPK IALLFTGQGS QYVNMGRQLY
QQAPVFRKAL EQCNEILLGT ETFREKSLLE ILYPANQEQS NSSLLDQTAY TQPCLFALEY
ALFKLWQSWG IQPDVVMGHS VGEYVAATVA GVFSLEEGLK LIAARGRLMQ QLPAGGEMVS
VIASESKVLE IFKAMSLEEK VAIAAINGPE STVISGEAEA VGAIATHLES LSIKTKQLQV
SHAFHSRLME PMLAEFEAVA KQVTYSQPQI SLISNVTGQQ VGSEITSAEY WVNHVRQPVR
FSESMTTLHQ EGYELFLEIG PKPILLGMGR QCLPEGVGVW LPSLRPGVEA WQQMLQSLGQ
LYMKGIKVNW SGFDQDYACH KVAIPTYPFQ RESYWIDTDK NQGQKAVNGS SSLIVDLLNQ
SDIEGLNQEL SFSTELTADE QKMLPKLLGI LVNRHQDYLE FKGNVVYDYY NSFAEISQEK
LSKEKQQENN SLQFLTFGIL PESIPGFSWL KMLTNSNQNP THKTALLEAQ QELRRLCFSQ
VDFSSTKKVL DFGCGYGSDL ITLAKNHPHL QLNGYTISSG QAKFAANQVN DYQLQEQIQI
FNRDSSKDEF PDNYNLAFGF EVAHHIKDKS LLFSNISRHL QEEGLLVMAD FIANSDVDID
HEETSSYFIT KQHWVEQLSP NKLQLISAID ISHEVSNYLY DAEFEENLRE LYEQNHDDNV
KSAFQSYNQL GKLLSKGLAS YVLLTAKKQE NLPQEQSYQL NREMLAQLSS YSEVAVKQWV
YELKWETKKH QQLLSPNKPG NWLIFADQQT QALKTVLAKQ NQNCLIVTPG SSYKQLDDQH
YQLNPTNAQE FQQLIKELFT TQDTLEGVVH LWNINTSTEE LEAAQELGCA SVLYLVQALV
SNSQSSIVPL WLVTQGTQNV EENEPKLAVQ QAPVWGLSRV IALEHPELKC RRVDLDQTRN
SLEALEALGK ELLNPDDEDQ IAIRGGVRYS ARLARRTQKS ISEQEQQIAF GTEGSYLLTG
GLGALGLEVA QWMVKQGARH IVLNGRRTPS ETAQETIQQL EQTGAKISVI LGDVSKEEDV
ASILKQIEAS QAPLRGVIHA AGFLDDGVLQ QMSWERFRKV MAPKLQGAWY LHQLTQKLPL
DFFVCFSSIA SLLGSPGQGN YAAANAFMDT LADYRRSMGL PGLSINWGAW AQGGMASRLG
SQHQSRLRTT GMNLITPEKG LQVLGELLSQ PVSQVGVFPI NWSQFLGQLP VGHTISFLEA
FASRKLQKET TKDENFLEQL ALAIESERNQ ILIGXLXVIV GKLLGFDKXK LXNPELGFFD
MGMDSLLTVE LRNLLSSNLG CSISAAELFG TSNIQNLAEH LIKEILPEGQ EEEEVDLDDS
QNTQNLDSAQ IETQGKVDHA IAAELQEIKN LLKEGN
//
