ID Q6FWJ6_CANGA Unreviewed; 635 AA.
AC Q6FWJ6;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Candida glabrata strain CBS138 chromosome C complete sequence {ECO:0000313|EMBL:CAG58304.1};
GN Name=HLP {ECO:0000313|CGD:CAL0127240};
GN OrderedLocusNames=CAGL0C05159g {ECO:0000313|CGD:CAL0127240,
GN ECO:0000313|EMBL:CAG58304.1};
OS Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
OS NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX NCBI_TaxID=284593 {ECO:0000313|EMBL:CAG58304.1, ECO:0000313|Proteomes:UP000002428};
RN [1] {ECO:0000313|EMBL:CAG58304.1, ECO:0000313|Proteomes:UP000002428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC {ECO:0000313|Proteomes:UP000002428};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CR380949; CAG58304.1; -; Genomic_DNA.
DR RefSeq; XP_445398.1; XM_445398.1.
DR AlphaFoldDB; Q6FWJ6; -.
DR STRING; 284593.Q6FWJ6; -.
DR EnsemblFungi; CAGL0C05159g-T; CAGL0C05159g-T-p1; CAGL0C05159g.
DR GeneID; 2886790; -.
DR KEGG; cgr:CAGL0C05159g; -.
DR CGD; CAL0127240; HLP.
DR VEuPathDB; FungiDB:CAGL0C05159g; -.
DR eggNOG; KOG2118; Eukaryota.
DR HOGENOM; CLU_011310_3_1_1; -.
DR InParanoid; Q6FWJ6; -.
DR OMA; DIHQHIM; -.
DR Proteomes; UP000002428; Chromosome C.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IEA:EnsemblFungi.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR GO; GO:0007005; P:mitochondrion organization; IEA:EnsemblFungi.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF100; PROTEIN MAM3; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000002428};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 42..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..221
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 302..367
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 421..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..635
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 70543 MW; 8911E6D09AFD499E CRC64;
MNSVAYSSIR YLPLLLRYGR ALPLLNNPHA LEQEHHESES DLVYYGVVSM FLVVLGGVFA
GLTLGLMGQD EIYLTVINTS GTQKEKQLSG KVLRLISRGK HWVLVTLLLS NVITNETLPI
VLDRCLNGGW QAVISSTILI VVFGEIIPQS ICVKYGLEVG AFFAPFVLVL MYLMYPVAYP
IALLLDYILG EDHGTVYKKS GLKTLVTLHQ TMGVERLTTD EVTIISAVLD LKDKKVKEIM
TPIENVFTLS ADKILDEKTI EEIFNSGFSR IPIHLPNEPM NFIGMLIVRI LISYDPEDAL
PISSFPLATL PETSPNTSCL NILNYFQEGK SHMCIVSERP GSSNGSIGVV TLEDVIEELI
GEEIVDESDV FVDIHQHIMR EQPGPLSKRH VTSYLHHLYT TSSKDSCVPL LNSKLNNYSS
INEHKPVNHS HPPNLPNGSQ LQLAPSNLAS NPLDIKKSFV TIKKLPPGEL ISPSNKDYSN
EHLRLNEQQG ENRRLSQGEQ QLLQEHANLS HKAIDYTQSS GKPIRITSST TTHDPNENGT
EDSAKNVLIS SSYQSTANGI VESVITVKGV AKTIIEDDQS VYHDNHEIQH DISKMNSSTD
LLLADHDEKS RSSTPVSDNG KKKKKSKKKK RRSKK
//
