ID Q6GL36_XENTR Unreviewed; 876 AA.
AC Q6GL36;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Villin 1 {ECO:0000313|EMBL:AAH74679.1};
DE SubName: Full=Villin-like protein {ECO:0000313|RefSeq:NP_001005657.1};
GN Name=vill {ECO:0000313|RefSeq:NP_001005657.1,
GN ECO:0000313|Xenbase:XB-GENE-945607};
GN Synonyms=vil1 {ECO:0000313|EMBL:AAH74679.1,
GN ECO:0000313|RefSeq:NP_001005657.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH74679.1};
RN [1] {ECO:0000313|RefSeq:NP_001005657.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH74679.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH74679.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001005657.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
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DR EMBL; BC074679; AAH74679.1; -; mRNA.
DR RefSeq; NP_001005657.1; NM_001005657.1.
DR GeneID; 448145; -.
DR KEGG; xtr:448145; -.
DR AGR; Xenbase:XB-GENE-945607; -.
DR CTD; 50853; -.
DR Xenbase; XB-GENE-945607; vill.
DR OMA; TINKMRM; -.
DR OrthoDB; 25995at2759; -.
DR Proteomes; UP000008143; Chromosome 6.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd11290; gelsolin_S1_like; 1.
DR CDD; cd11289; gelsolin_S2_like; 1.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11293; gelsolin_S4_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.40.20.10; Severin; 6.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR PANTHER; PTHR11977; VILLIN; 1.
DR PANTHER; PTHR11977:SF30; VILLIN-LIKE PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 6.
DR Pfam; PF02209; VHP; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 4.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 2.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
PE 2: Evidence at transcript level;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 810..876
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
FT REGION 744..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 98599 MW; 4BBFA088E846668C CRC64;
MTQNLENMCR KPGLQIWSME KMKLVPIPEK AYGSFFEGDC YILLYNKQTP NGLISDIHYW
IGKDSSQDEQ GSAAFYATQI DGLLGGGPIQ HREVQGHESA TFKSYFKNGV IYKKGGVSSG
FKHVETNMYN IRRLLHVKGK KHVTATEVAM SWNSFNKGDV FLLDLGKVII QWNGPESNKS
ERIRACSLAQ SIRDDERGGR AQIGVIDNEQ DSPDLMQIMV AVLGARTGEL KDSVPDEKAD
EQQKANVRLY HVFEKDANLV VQELATKPLT QDLLQHEDCH ILDQGGVKIY VWRGKNSSPE
EKSAAFSRAV GFIQAKGYPP TTNVEVVNDG AESAMFKQLF QNWKDVGETQ GLGKTFSVGK
IAKVEQTKFD VNQLYARPEL AAEQRMVDDA SGNVEVWRIE KLELAEVEPR TYGQFYGGDC
YLILYTYMKS GRPNYLLYMW LGRHASQDEI TACAFQAVQL DKKYHDQPVQ IRVTMGKEPR
HLQAMFKGKM IIYEGGTSRL GVHEPEAPIK LFQVKGTNEY NTKATEVPAR ASSLNSNDVF
VLKTESMCYL WCGKGCSGDE REMAKTVANI ISKQDKQTIL EGQEPAEFWV ALGGKAPYAS
DKRFQEQAVQ YSPRLFECSN QTGRFVMTEV VDFCQSDLDE DDVMLLDTWE EIFLWVGKSA
NDYEKTESVK ASQEYLRAHP AGRDLATPII LVKQGHEPPT FTGWFNAWDS HKWSSDLSYE
DMKKTLGDVS AISQISVDLQ NTNLNKKSTS NAPPTSSAPP TSSAPESVPI PMYRSHSQEN
LQYNNGHQAT TNGSQVPNQV KQNPEPLPES NGNQWFDRSF LINKVTEDLP DGVDPTKKEM
YLSDADFAAI MGMPKAQFYQ MPKWKQQNLK KQHGLF
//
