ID Q6GP36_XENLA Unreviewed; 555 AA.
AC Q6GP36;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=MGC80715 protein {ECO:0000313|EMBL:AAH73312.1};
DE SubName: Full=Serine palmitoyltransferase, long chain base subunit 2 S homeolog {ECO:0000313|RefSeq:NP_001085763.1};
DE EC=2.3.1.50 {ECO:0000313|RefSeq:NP_001085763.1};
GN Name=sptlc2.S {ECO:0000313|RefSeq:NP_001085763.1,
GN ECO:0000313|Xenbase:XB-GENE-946147};
GN Synonyms=MGC80715 {ECO:0000313|EMBL:AAH73312.1}, sptlc2
GN {ECO:0000313|RefSeq:NP_001085763.1,
GN ECO:0000313|Xenbase:XB-GENE-946147};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH73312.1};
RN [1] {ECO:0000313|RefSeq:NP_001085763.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH73312.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen {ECO:0000313|EMBL:AAH73312.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001085763.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU003693};
CC -!- SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000256|ARBA:ARBA00008392,
CC ECO:0000256|RuleBase:RU003693}.
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DR EMBL; BC073312; AAH73312.1; -; mRNA.
DR RefSeq; NP_001085763.1; NM_001092294.1.
DR DNASU; 444190; -.
DR GeneID; 444190; -.
DR KEGG; xla:444190; -.
DR AGR; Xenbase:XB-GENE-946147; -.
DR CTD; 444190; -.
DR Xenbase; XB-GENE-946147; sptlc2.S.
DR OrthoDB; 9643at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 444190; Expressed in lung and 19 other cell types or tissues.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd06454; KBL_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001917; Aminotrans_II_pyridoxalP_BS.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR13693; CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE; 1.
DR PANTHER; PTHR13693:SF79; SERINE PALMITOYLTRANSFERASE 2; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00599; AA_TRANSFER_CLASS_2; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|RuleBase:RU003693};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transferase {ECO:0000256|ARBA:ARBA00023315}.
FT DOMAIN 162..521
FT /note="Aminotransferase class I/classII"
FT /evidence="ECO:0000259|Pfam:PF00155"
SQ SEQUENCE 555 AA; 62287 MW; 8F9BE45DAC3F4153 CRC64;
MTRFGAVEIS AGLSHSYKPV MNGIRSCENG TLRNGMIAEE KVHNGGLYKR SFNEAFEETP
MIVAVLTYMG YGILTLFGYL RDFLRTWKIE KCHIATERDE QKDFVPLYQD FENFYTRNLY
MRIRDNWNRP VCSVPGERID LMERFTDDYN WTFKFTGRVI KGVINMGSYN YLGFAQNTGL
CADASAKALS QYGVGMCSTR QEIGNMDKHE ELEQLVAKFL GVEAAMTYGM GFATNSMNIP
ALVGKGCLIL SDELNHSSLV LGARLSGATI RIFKHNKMQS LEKLLRDAIV QGQPRTHRPW
KKILIVVEGI YSMEGSIVRL PDVIALKKKY KAYLYLDEAH SIGALGPNGR GVVDYFGLDP
RDVDIMMGTF TKSFGSAGGY IGGSKVLIDY LRAHSHSSAY ATSMSPPVAQ QIISSMKCIM
GEDGSTVGRK HVEQLAENTK YFRHRLTEMG FIIYGNSDSP VVPLMLYMPA KIGAFGREML
KRNIGVVVVG FPATPIIESR ARFCVSAAHT KEMLDAALRE INEVGDLLQL KYSRHLFVPL
LDRPFDETTY EETED
//
