ID Q6H053_9CYAN Unreviewed; 136 AA.
AC Q6H053;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Putative ferric uptake regulatory protein {ECO:0000313|EMBL:AAT41916.1};
OS Fremyella diplosiphon Fd33.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Tolypothrichaceae;
OC Tolypothrix; Tolypothrix sp. PCC 7601.
OX NCBI_TaxID=293451 {ECO:0000313|EMBL:AAT41916.1};
RN [1] {ECO:0000313|EMBL:AAT41916.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Fd33 {ECO:0000313|EMBL:AAT41916.1};
RX PubMed=15205436; DOI=10.1128/JB.186.13.4338-4349.2004;
RA Stowe-Evans E.L., Ford J., Kehoe D.M.;
RT "Genomic DNA microarray analysis: identification of new genes regulated by
RT light color in the cyanobacterium Fremyella diplosiphon.";
RL J. Bacteriol. 186:4338-4349(2004).
RN [2] {ECO:0000313|EMBL:AAT41916.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Fd33 {ECO:0000313|EMBL:AAT41916.1};
RA Stowe-Evans E., Ford J., Kehoe D.M.;
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|PIRSR:PIRSR602481-2};
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR602481-2};
CC Note=Binds 1 Mn(2+) or Fe(2+) ion per subunit.
CC {ECO:0000256|PIRSR:PIRSR602481-2};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR602481-1};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602481-1};
CC -!- SIMILARITY: Belongs to the Fur family. {ECO:0000256|ARBA:ARBA00007957}.
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DR EMBL; AY548448; AAT41916.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6H053; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07153; Fur_like; 1.
DR Gene3D; 3.30.1490.190; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002481; FUR.
DR InterPro; IPR043135; Fur_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33202:SF19; FERRIC UPTAKE REGULATION PROTEIN; 1.
DR PANTHER; PTHR33202; ZINC UPTAKE REGULATION PROTEIN; 1.
DR Pfam; PF01475; FUR; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Iron {ECO:0000256|PIRSR:PIRSR602481-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602481-1};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR602481-1}.
FT BINDING 83
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 86
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 115
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-2"
FT BINDING 123
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 126
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
SQ SEQUENCE 136 AA; 15579 MW; 3B7060C47DBDAF79 CRC64;
MSMRAIRTRS QDKILNLLKN IKQGISAQDI YVELRNRNQS MGLATVYRSL EALKMEGLVQ
IRTLANGEAL YSLAQQDKHH LTCLQCGVSI PINQCPVHDL EEKLQEKHKF KIFYHTLEFF
GLCTQCQSNQ AAEVNE
//
