ID Q6IR79_XENLA Unreviewed; 385 AA.
AC Q6IR79;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=CCN family member 1 {ECO:0000256|ARBA:ARBA00039941};
DE AltName: Full=Cellular communication network factor 1 {ECO:0000256|ARBA:ARBA00042351};
DE AltName: Full=Protein CYR61 {ECO:0000256|ARBA:ARBA00042204};
GN Name=ccn1l.L {ECO:0000313|RefSeq:NP_001085010.1,
GN ECO:0000313|Xenbase:XB-GENE-22064066};
GN Synonyms=ccn1l {ECO:0000313|Xenbase:XB-GENE-22064066}, cyr61l
GN {ECO:0000313|RefSeq:NP_001085010.1}, MGC82209
GN {ECO:0000313|EMBL:AAH71021.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH71021.1};
RN [1] {ECO:0000313|RefSeq:NP_001085010.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH71021.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH71021.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001085010.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR EMBL; BC071021; AAH71021.1; -; mRNA.
DR RefSeq; NP_001085010.1; NM_001091541.1.
DR DNASU; 432074; -.
DR GeneID; 432074; -.
DR KEGG; xla:432074; -.
DR AGR; Xenbase:XB-GENE-22064066; -.
DR CTD; 432074; -.
DR Xenbase; XB-GENE-22064066; ccn1l.L.
DR OrthoDB; 2970572at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 432074; Expressed in muscle tissue and 16 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348:SF18; CCN FAMILY MEMBER 1; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..385
FT /note="CCN family member 1"
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001085010.1"
FT /id="PRO_5033206782"
FT DOMAIN 26..98
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 102..168
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 290..364
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 385 AA; 42658 MW; C2270D246E95FA97 CRC64;
MRSLAALLPL LQLAALICTG TSGKLMEASC PTQCVCPKEV QSCPPGISLL TDSCGCCKVC
ARQYNQDCGL NHPCDHIKGL HCDYGADPFS PRGICRAKSE GRPCEFFGQI YQNGENFQPN
CKHQCTCMDG VVGCMPLCPQ EMALPGVDCI NPRLVKVPGQ CCEVWQCDSN HISEDSGDTT
TGDGEDPVRS SEEIGELADI EPVSSNELIS LVRNGFRVEN GLAPLPHPGK TTCAIQTTEW
SQCSKSCNMG VSTRITNDNP HCKLMKETRL CEIRPCQDPF PTMSKNGKKC VRTKKAKQAV
HIPYAGCTSV RQYKPLYCGS CTDGRCCTPS KTRTMRVRFR CEDGDTFQKS MMWVQKCKCH
QDCPYHSELS YPHYRLHNDI HKFKD
//
