ID Q6IRQ1_XENLA Unreviewed; 657 AA.
AC Q6IRQ1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 130.
DE SubName: Full=70 kDa peroxisomal membrane protein {ECO:0000313|EMBL:ABK62837.1};
DE SubName: Full=ATP binding cassette subfamily D member 3 S homeolog {ECO:0000313|RefSeq:NP_001084980.1, ECO:0000313|RefSeq:XP_018115053.1};
DE SubName: Full=ATP binding cassette subfamily D member 3 S homeolog isoform X2 {ECO:0000313|RefSeq:XP_018115052.1};
DE SubName: Full=MGC82231 protein {ECO:0000313|EMBL:AAH70657.1};
GN Name=abcd3.S {ECO:0000313|RefSeq:NP_001084980.1,
GN ECO:0000313|RefSeq:XP_018115052.1, ECO:0000313|RefSeq:XP_018115053.1,
GN ECO:0000313|Xenbase:XB-GENE-983905};
GN Synonyms=abcd3 {ECO:0000313|RefSeq:NP_001084980.1,
GN ECO:0000313|RefSeq:XP_018115052.1, ECO:0000313|RefSeq:XP_018115053.1,
GN ECO:0000313|Xenbase:XB-GENE-983905}, MGC82231
GN {ECO:0000313|EMBL:AAH70657.1}, pmp70
GN {ECO:0000313|RefSeq:NP_001084980.1, ECO:0000313|RefSeq:XP_018115052.1,
GN ECO:0000313|RefSeq:XP_018115053.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH70657.1};
RN [1] {ECO:0000313|RefSeq:NP_001084980.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH70657.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000313|EMBL:AAH70657.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ABK62837.1, ECO:0000313|RefSeq:NP_001084980.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17973332; DOI=10.1002/dvdy.21370;
RA Cooper C.A., Walsh L.A., Damjanovski S.;
RT "Peroxisome biogenesis occurs in late dorsal-anterior structures in the
RT development of Xenopus laevis.";
RL Dev. Dyn. 236:3554-3561(2007).
RN [4] {ECO:0000313|RefSeq:XP_018115052.1, ECO:0000313|RefSeq:XP_018115053.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018115052.1,
RC ECO:0000313|RefSeq:XP_018115053.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018115052.1,
RC ECO:0000313|RefSeq:XP_018115053.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very long-chain fatty acid(in) + ATP + H2O = a very long-
CC chain fatty acid(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:67080,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58950, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00024576};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67081;
CC Evidence={ECO:0000256|ARBA:ARBA00024576};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very long-chain fatty acyl-CoA + H2O = a very long-chain
CC fatty acid + CoA + H(+); Xref=Rhea:RHEA:67072, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950,
CC ChEBI:CHEBI:138261; Evidence={ECO:0000256|ARBA:ARBA00024544};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67073;
CC Evidence={ECO:0000256|ARBA:ARBA00024544};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Peroxisome
CC membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004585}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCD family.
CC Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
CC {ECO:0000256|ARBA:ARBA00008575}.
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DR EMBL; BC070657; AAH70657.1; -; mRNA.
DR EMBL; EF070607; ABK62837.1; -; mRNA.
DR RefSeq; NP_001084980.1; NM_001091511.1.
DR RefSeq; XP_018115052.1; XM_018259563.2.
DR RefSeq; XP_018115053.1; XM_018259564.2.
DR STRING; 8355.Q6IRQ1; -.
DR PaxDb; 8355-Q6IRQ1; -.
DR DNASU; 432040; -.
DR GeneID; 432040; -.
DR KEGG; xla:432040; -.
DR AGR; Xenbase:XB-GENE-983905; -.
DR CTD; 432040; -.
DR Xenbase; XB-GENE-983905; abcd3.S.
DR OMA; IHDMYLD; -.
DR OrthoDB; 7698at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 432040; Expressed in stomach and 19 other cell types or tissues.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005324; F:long-chain fatty acid transporter activity; IEA:InterPro.
DR GO; GO:0015910; P:long-chain fatty acid import into peroxisome; IEA:InterPro.
DR CDD; cd03223; ABCD_peroxisomal_ALDP; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005283; FA_transporter.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00954; 3a01203; 1.
DR PANTHER; PTHR11384:SF62; ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3; 1.
DR PANTHER; PTHR11384; ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER; 1.
DR Pfam; PF06472; ABC_membrane_2; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 123..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..319
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 438..657
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 657 AA; 75039 MW; DC12D6A1A870D096 CRC64;
MAPVYSKYLN ARNTSVAGAA LFLLYLISKR RGASGKKNGK SSLQNNEKDG KKEKAVVDRV
FFGRIGQILK ILVPKTFCKE SGYLLFIAVM LIARTYCDVW MIQNGTFIES AIIGRSRKDF
KRYLFNFIAA MPAISLVNNF LKFGLNELKL CFRERLTKYL YDEYLKSFTY YKMGNLDNRI
ANADQLLTQD VERFCNSVVD LYSNLSKPFL DIVLYIFKLT SAIGAQGPAS MMAYLLVSGL
FLTRLRRPIG KMTVAEQRYE GEYRYVNSRL ITNSEEIAFY NGNKREKLTI YSSFQKLVEH
LHNFILFRFS MGFVDSIIAK YLATVVGYLV VSRPFLAINH PRHLNSSHAE LLEDYYQSGR
MLLRMSQALG RIVLAGREMT RLSGFTARIT ELMQVLKDLN QGKYERTMVS QQDKDVEAVP
SIPLIPGSGK VINADKIIKF DHVPLATPNG DLLIRDLNFE VRSGTNVLVC GPNGCGKSSL
FRVLGELWPL FGGSLTKPER GKLFYVPQRP YMTLGTLRDQ VIYPDTQEDQ KRKGISDKVL
KEYLDNVQLG HILDREGGWD SVQDWMDVLS GGEKQRMAMA RLFYHKPQFA ILDECTSAVS
VDVEGYIYNH CRKVGITLFT VSHRKSLWKH HEYYLHMDGR GNYDFKQITE DTDAFGS
//
