ID Q6IRR1_XENLA Unreviewed; 459 AA.
AC Q6IRR1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=MGC81342 protein {ECO:0000313|EMBL:AAH70613.1};
DE SubName: Full=Signal transducing adaptor molecule L homeolog {ECO:0000313|RefSeq:NP_001084997.1};
GN Name=stam.L {ECO:0000313|RefSeq:NP_001084997.1,
GN ECO:0000313|Xenbase:XB-GENE-864873};
GN Synonyms=MGC81342 {ECO:0000313|EMBL:AAH70613.1}, stam
GN {ECO:0000313|RefSeq:NP_001084997.1,
GN ECO:0000313|Xenbase:XB-GENE-864873};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH70613.1};
RN [1] {ECO:0000313|RefSeq:NP_001084997.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH70613.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH70613.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001084997.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}.
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
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DR EMBL; BC070613; AAH70613.1; -; mRNA.
DR RefSeq; NP_001084997.1; NM_001091528.1.
DR DNASU; 432059; -.
DR GeneID; 432059; -.
DR KEGG; xla:432059; -.
DR AGR; Xenbase:XB-GENE-864873; -.
DR CTD; 432059; -.
DR Xenbase; XB-GENE-864873; stam.L.
DR OrthoDB; 620063at2759; -.
DR Proteomes; UP000186698; Chromosome 6L.
DR Bgee; 432059; Expressed in testis and 19 other cell types or tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd21389; GAT_STAM1; 1.
DR CDD; cd11964; SH3_STAM1; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 6.10.140.100; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR047492; GAT_STAM1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035657; STAM1_SH3.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF2; SIGNAL TRANSDUCING ADAPTER MOLECULE 1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02809; UIM; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00726; UIM; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
PE 2: Evidence at transcript level;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 16..143
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 208..267
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 433..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 50694 MW; 7D2A6968418E5DB7 CRC64;
MPLFTSNPFD PDVEKATSEL NTAEDWGLIL DLCDKVGQSR TGPKDCLRSI MRRVNHKDPH
VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSSVLNKG HPKVCEKLKA LMVEWAEEFK
NDPQLSLISA MIKNLKEQGV TFPAVGSQAA EQAKASPALV TKDPGTVAIK KEEEDLAKAI
ELSLKEQKQQ STVSGLYPST SLLTALKPEG RKVQAIYDFE AAEDNELTFK AGDIVTVLDD
SDPNWWKGET NEGTGLFPSN FVTADLSAEL EIIKTDKKTV QFSDEVQVET IEPEPEPVYI
DEDKMDHLLQ MLQSADPTDG LPDPADLLHL EAACHQMGPL IDEKLEDIDR KHSELSELNV
KVMEALSFYT KLMNEDPMYS MYAKMQNQQF YMQSAAVPPQ QSYQGPHPNA AYIVTGNTQM
GHIQTYPVPA EQLPSLNQGA VPHPASSELP SQSQQASYK
//