ID   Q6L884_9EUGL            Unreviewed;      1027 AA.
AC   Q6L884;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   22-FEB-2023, entry version 62.
DE   SubName: Full=Putative alpha subunit of photoactivated adenylyl cyclase {ECO:0000313|EMBL:BAD20734.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:BAD20734.1};
OS   Euglena quartana.
OC   Eukaryota; Discoba; Euglenozoa; Euglenida; Spirocuta; Euglenophyceae;
OC   Euglenales; Euglenaceae; Euglena.
OX   NCBI_TaxID=56462 {ECO:0000313|EMBL:BAD20734.1};
RN   [1] {ECO:0000313|EMBL:BAD20734.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15170488; DOI=10.1039/b316075k;
RA   Koumura Y., Suzuki T., Yoshikawa S., Watanabe M., Iseki M.;
RT   "The origin of photoactivated adenylyl cyclase (PAC), the Euglena blue-
RT   light receptor: phylogenetic analysis of orthologues of PAC subunits from
RT   several euglenoids and trypanosome-type adenylyl cyclases from Euglena
RT   gracilis.";
RL   Photochem. Photobiol. Sci. 3:580-586(2004).
CC   -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits.
CC       {ECO:0000256|ARBA:ARBA00011103}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000256|ARBA:ARBA00004230}.
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DR   EMBL; AB126949; BAD20734.1; -; mRNA.
DR   AlphaFoldDB; Q6L884; -.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009882; F:blue light photoreceptor activity; IEA:InterPro.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 2.
DR   Gene3D; 3.30.70.100; -; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR036046; Acylphosphatase-like_dom_sf.
DR   InterPro; IPR007024; BLUF_domain.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF04940; BLUF; 2.
DR   Pfam; PF00211; Guanylate_cyc; 2.
DR   SMART; SM01034; BLUF; 2.
DR   SUPFAM; SSF54975; Acylphosphatase/BLUF domain-like; 2.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50925; BLUF; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE   2: Evidence at transcript level;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW   Lyase {ECO:0000313|EMBL:BAD20734.1};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          55..148
FT                   /note="BLUF"
FT                   /evidence="ECO:0000259|PROSITE:PS50925"
FT   DOMAIN          204..332
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   DOMAIN          467..559
FT                   /note="BLUF"
FT                   /evidence="ECO:0000259|PROSITE:PS50925"
FT   DOMAIN          615..744
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          416..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1027 AA;  112350 MW;  FC99DB56C3FCBA39 CRC64;
     MYILVWKDGQ QVKNFQDLEE CGAFQTAANI VDGQIFNVGV TSAMNKGGDT GEVQLRRLMY
     LSASTEPEEC TTEYLAELAR ASSLRNKEIG VSGFLLYSAP FFFQVIEGTD EDLDFLFAKI
     SSDPRHEKCI VLANGPCTGR LYGEWHMKDS HIDNITKHPA IKTILFQIAK SFSSMWSYLS
     KNTANMLLLG KQPNKQAPEP MSVVISFIYL VEFSSILAHP GLTEQCADVL AAFVDVCVRN
     IEGTGGHVAK FITGICMAYW PSNRAEDALV GLQQLSDDLA ELRSQQPPGS ALSLVYSRCG
     VHYGRALLCN AGIKKADFTL LGDCINTASR ITSLAGKLKV PLLLSFEVRC LLGAEMREEL
     ESAGMHKVKG REQPVQVFYF NAAEVDSTAV RAKIEQFNPG RYRALCPVKP YDSLHPSQKP
     PIFDDTPRDS MPRSGHLQRQ DSLVDRLSMI AKLAFPPSMA AGGESQLIGL TYISQASHAM
     SRLDLSDIQR VAHRRNEQVN ISACLLYING LFVQTLEGPK SAVVSLYLKI RQDPRHKDVV
     VVHMAPLEER MYRGPLDTTC ATDEMLATFP PLQDVLSQLA KSFISLETYV PSTIVRYLTS
     GNNPRNLQPV SLEVVMLATD ICSFTPLSEH CSLTEIWTIC NTFIDACTSA ICSQGGEVIK
     LIGDCVTAYF PPTSADNAVY ACQDIVAFCA NLREAFRDVL DCRSVVACGV GLDFGQVIMA
     QCGSSGLTEF AVAGEVSARV MEVEALTREA GRAIVLTEPV ADHLSPKLRD NGLVPCQEGV
     DGVPCYGILG AEWELDVVTI KRNIQNFHAA RAVAAVQKVD DGMNAPGRAL PVASMPAISS
     PSPKVRTAGR AASVASYAPD LNDLLDPRMA EVVFQELCQQ RGEIPNNAVL LRLRQAAHEE
     RADLGRSLQG PHELPPLTQA LKQLTNVRAL NMSDNFVDDT SIGDLIESCL AMRSLQMLDL
     SNNPGLTKVI ALKRLIKHNP QLREIHLNGT RIAPTEQRKL QSSLNVNRLC ASAESKLGSH
     KYEGAAH
//