ID Q6LVX6_PHOPR Unreviewed; 370 AA.
AC Q6LVX6;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=ThiH protein {ECO:0000313|EMBL:CAG18549.1};
GN Name=Z5564 {ECO:0000313|EMBL:CAG18549.1};
GN OrderedLocusNames=PBPRA0110 {ECO:0000313|EMBL:CAG18549.1};
OS Photobacterium profundum (strain SS9).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Photobacterium.
OX NCBI_TaxID=298386 {ECO:0000313|EMBL:CAG18549.1, ECO:0000313|Proteomes:UP000000593};
RN [1] {ECO:0000313|Proteomes:UP000000593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1253 / SS9 {ECO:0000313|Proteomes:UP000000593};
RX PubMed=15746425; DOI=10.1126/science.1103341;
RA Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M.,
RA Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C.,
RA Bartlett D.H., Valle G.;
RT "Life at depth: Photobacterium profundum genome sequence and expression
RT analysis.";
RL Science 307:1459-1461(2005).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CR378663; CAG18549.1; -; Genomic_DNA.
DR RefSeq; WP_011216927.1; NC_006370.1.
DR AlphaFoldDB; Q6LVX6; -.
DR STRING; 298386.PBPRA0110; -.
DR KEGG; ppr:PBPRA0110; -.
DR eggNOG; COG0502; Bacteria.
DR HOGENOM; CLU_046249_1_0_6; -.
DR Proteomes; UP000000593; Chromosome 1.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDG01081; cleavage_of_the_Ca-Cb_bond_in; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000593};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 70..297
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 370 AA; 42458 MW; 7B992AF71DA18EDC CRC64;
MSYVDVWKQL NWDDVRLSIY SKTATDVERA LRKPKRDLED FKALISPAAE PYLEQMAQQS
AALTRKRFGH TMSFYVPLYL SNLCANACTY CGFSMENRIK RRTLTLEEIN QECQAIKAMN
FDSILLVTGE HERKVGMEYF RESVPAIKQQ FSYLAMEVQP LEQEEYAELK TLGLDAVMVY
QETYSAPTYA EHHLRGNKMD FEYRLATPDR LAKAGIDKIG IGALIGLEEW RTDCFFAATH
LDYLERTYWQ TRYSISFPRL RPCEGGLQPK SIMSDRQLVQ LICAYRMFNP QVELSLSTRE
SPEFRDNVLP LGVTSMSAGS KTQPGGYAND EPELEQFSIS DDRSVADVAA AVKRNGFEVV
WKDWHHAYSG
//
