ID   Q6M9E0_NEUCS            Unreviewed;       825 AA.
AC   Q6M9E0;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Spindle assembly checkpoint component MAD1 {ECO:0000256|ARBA:ARBA00022019};
GN   ORFNames=G21B4.330 {ECO:0000313|EMBL:CAF06018.1}, GE21DRAFT_6083
GN   {ECO:0000313|EMBL:KHE88581.1};
OS   Neurospora crassa.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=5141 {ECO:0000313|EMBL:CAF06018.1};
RN   [1] {ECO:0000313|EMBL:CAF06018.1}
RP   NUCLEOTIDE SEQUENCE.
RA   German Neurospora genome project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAF06018.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Schulte U., Aign V., Hoheisel J., Brandt P., Fartmann B., Holland R.,
RA   Nyakatura G., Mewes H.W., Mannhaupt G.;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KHE88581.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=73 {ECO:0000313|EMBL:KHE88581.1};
RG   DOE Joint Genome Institute;
RA   Baker S.E., Grigoriev I., Haridas S., LaButti K., McCluskey K.;
RT   "Draft genome sequence of Neurospora crassa strain FGSC 73.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the MAD1 family.
CC       {ECO:0000256|ARBA:ARBA00008029}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX908808; CAF06018.1; -; Genomic_DNA.
DR   EMBL; KN389634; KHE88581.1; -; Genomic_DNA.
DR   VEuPathDB; FungiDB:NCU04428; -.
DR   eggNOG; KOG4593; Eukaryota.
DR   HOGENOM; CLU_010064_0_0_1; -.
DR   OrthoDB; 2787310at2759; -.
DR   Proteomes; UP000053122; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   Gene3D; 3.30.457.60; -; 1.
DR   Gene3D; 6.10.250.90; -; 1.
DR   InterPro; IPR008672; Mad1.
DR   PANTHER; PTHR23168:SF0; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1; 1.
DR   PANTHER; PTHR23168; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1; 1.
DR   Pfam; PF05557; MAD; 1.
DR   SUPFAM; SSF75704; Mitotic arrest deficient-like 1, Mad1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   REGION          1..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          173..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          541..578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          801..825
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          329..390
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          439..466
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          668..695
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        55..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..118
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..555
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        559..577
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   825 AA;  92020 MW;  1384DBA9B1798B24 CRC64;
     MPPSSIPQPG QGKPPLRRGS ISGPSGPQAQ FRASIGASAI PRPQTALRGS RPGSFRASIS
     AQPSFASNPS GDSHIPLSIA NLSRSSSRQG RTPTGPSPPP ANDETAASST NPTRDSSKEN
     IAPPDAAEYE AQRRRIEELK AEVGTLTYQI SNYEQEKELG RLQMENEMRD IRRQAEQDFK
     AKQAADAEKS KALRHAESLQ AELDALRAEK ETQKRELNAK TRETQEEARL LREQVEELKA
     AKEEAARLAE REITELKAKV TVLERTAQET EEENRTLKDT LEKVNAQLAE RDDTIGKLDA
     EVLRLKAHTG DAETVSVIRR ELSDQVNHIR MLESKNREQI TELKHLRQVY KAVEVVEEEK
     RTLQRKLEAA QTLETELAEE RRQRLRLEDE RRSWTAYLES NSEGPVEFDS PEAVARALVE
     ERFRSASLTE RLGALQPEIA DRDNIIKSLE DEKARLLEQI EKLRASSGPS ANDKARARLD
     RQRALAVKEV EYLRAQLKTF DMEDVTMQPE QLDEQKAKRI QELEDLVDKY KEEVNTLHAD
     LTSLESASTS PVQPVLAGTK RPRDDHDGAE SEQLGQLARK NRKLQSEFSD LQTAHRILQK
     EHEVTTSQLA AAKEQLKTRI LSLRDNPTSE YEKIKTDTLK ALKLENAELL AHLERQPTLF
     ATVPATQIAA LKREISAAQA ETASAQKRAD RLKQVWAAKS AEFKEAVFST LGWTVTFIPG
     GKMRVESVYY PSKTEEHENS IVFDGEKGTM KVGGGPRSEF ANRIADNIRF WVREKGEVPC
     FLAALTLEFY EEMHGAKQLQ AAAGGGESGS GSGTPMEGVT GTASA
//