ID Q6NL36_DROME Unreviewed; 391 AA.
AC Q6NL36;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=isocitrate dehydrogenase (NAD(+)) {ECO:0000256|ARBA:ARBA00013012};
DE EC=1.1.1.41 {ECO:0000256|ARBA:ARBA00013012};
DE AltName: Full=Isocitric dehydrogenase subunit alpha {ECO:0000256|ARBA:ARBA00042862};
DE AltName: Full=NAD(+)-specific ICDH subunit alpha {ECO:0000256|ARBA:ARBA00042642};
GN Name=CG3483 {ECO:0000313|EMBL:AAS93778.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAS93778.1};
RN [1] {ECO:0000313|EMBL:AAS93778.1}
RP NUCLEOTIDE SEQUENCE.
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Rubin G.M., Celniker S.;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAR92985.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MEL11 {ECO:0000313|EMBL:CAR92985.1}, MEL12
RC {ECO:0000313|EMBL:CAR92986.1}, MEL13 {ECO:0000313|EMBL:CAR92987.1},
RC MEL14 {ECO:0000313|EMBL:CAR92988.1}, MEL15
RC {ECO:0000313|EMBL:CAR92989.1}, MEL16 {ECO:0000313|EMBL:CAR92990.1},
RC MEL17 {ECO:0000313|EMBL:CAR92991.1}, MEL18
RC {ECO:0000313|EMBL:CAR92992.1}, MEL19 {ECO:0000313|EMBL:CAR92993.1},
RC and MEL20 {ECO:0000313|EMBL:CAR92994.1};
RX PubMed=19126864; DOI=10.1093/molbev/msn297;
RA Parsch J., Zhang Z., Baines J.F.;
RT "The influence of demography and weak selection on the McDonald-Kreitman
RT test: an empirical study in Drosophila.";
RL Mol. Biol. Evol. 26:691-698(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; BT012507; AAS93778.1; -; mRNA.
DR EMBL; FM245059; CAR92985.1; -; Genomic_DNA.
DR EMBL; FM245060; CAR92986.1; -; Genomic_DNA.
DR EMBL; FM245061; CAR92987.1; -; Genomic_DNA.
DR EMBL; FM245062; CAR92988.1; -; Genomic_DNA.
DR EMBL; FM245063; CAR92989.1; -; Genomic_DNA.
DR EMBL; FM245064; CAR92990.1; -; Genomic_DNA.
DR EMBL; FM245065; CAR92991.1; -; Genomic_DNA.
DR EMBL; FM245066; CAR92992.1; -; Genomic_DNA.
DR EMBL; FM245067; CAR92993.1; -; Genomic_DNA.
DR EMBL; FM245068; CAR92994.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6NL36; -.
DR VEuPathDB; VectorBase:FBgn0035005; -.
DR HOGENOM; CLU_031953_0_0_1; -.
DR ExpressionAtlas; Q6NL36; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 2: Evidence at transcript level;
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT DOMAIN 71..387
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
FT REGION 24..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 42914 MW; 4AAF62EC20370803 CRC64;
MNTLRKLNSL PPFRSVGGAY RLFAGKDQKK DSAGQKTRQP EKPPQDKQKS KGAIGKAKSA
GSTDSAKKTT KVTLINGEGV GRELMDAVQE VICAVKAPIE WDVHDEFKAK DSDDVSPEVL
KSLRANKVGI KGPVDSRHWQ RQIRKQFAQF AYVSLCSHIE GLDSPYGDFD VVIIRDQMEG
DYSGIEHLVV PGVMQTIKVS TTAGAARIAE FVFNYAVKNK RKRITVAHKA NIMRMTDGNF
LEAMRAEADK HVDDVLFEER YLDTCILKIL LKPHKCDVMV SSSMYGDVLR VIAGGMMGVP
GICPGYSVSS LGTVFDCRMK ACHALAGKDL ANPTGPLLSA ALMLRHVKMD KQADQVDCAI
RKVYKDTDIR TPDVGGKAKC SEFVKAVCDC L
//
