ID Y1411_DROME Reviewed; 710 AA.
AC Q6NLL1; Q6NMV3; Q960Z3;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 24-JAN-2024, entry version 115.
DE RecName: Full=WD repeat-containing protein CG11141;
GN ORFNames=CG11141;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head, and Testis;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 222-710.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-488, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the WD repeat KIAA0329 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK93183.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE013599; AAF59251.1; -; Genomic_DNA.
DR EMBL; BT011551; AAS15687.1; -; mRNA.
DR EMBL; BT012320; AAS77445.1; -; mRNA.
DR EMBL; AY051759; AAK93183.1; ALT_INIT; mRNA.
DR RefSeq; NP_001286159.1; NM_001299230.1.
DR RefSeq; NP_610282.1; NM_136438.4.
DR RefSeq; NP_724559.1; NM_165525.3.
DR AlphaFoldDB; Q6NLL1; -.
DR IntAct; Q6NLL1; 1.
DR STRING; 7227.FBpp0311785; -.
DR iPTMnet; Q6NLL1; -.
DR PaxDb; 7227-FBpp0088070; -.
DR DNASU; 35672; -.
DR EnsemblMetazoa; FBtr0088998; FBpp0088070; FBgn0033177.
DR EnsemblMetazoa; FBtr0088999; FBpp0088071; FBgn0033177.
DR EnsemblMetazoa; FBtr0345799; FBpp0311785; FBgn0033177.
DR GeneID; 35672; -.
DR KEGG; dme:Dmel_CG11141; -.
DR UCSC; CG11141-RA; d. melanogaster.
DR UCSC; CG11141-RB; d. melanogaster.
DR AGR; FB:FBgn0033177; -.
DR FlyBase; FBgn0033177; CG11141.
DR VEuPathDB; VectorBase:FBgn0033177; -.
DR eggNOG; KOG3621; Eukaryota.
DR GeneTree; ENSGT00940000157283; -.
DR HOGENOM; CLU_026810_0_0_1; -.
DR InParanoid; Q6NLL1; -.
DR OMA; TEFDYQA; -.
DR OrthoDB; 3675109at2759; -.
DR PhylomeDB; Q6NLL1; -.
DR BioGRID-ORCS; 35672; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 35672; -.
DR PRO; PR:Q6NLL1; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033177; Expressed in testis and 23 other cell types or tissues.
DR ExpressionAtlas; Q6NLL1; baseline and differential.
DR Genevisible; Q6NLL1; DM.
DR GO; GO:0005737; C:cytoplasm; IEA:GOC.
DR GO; GO:0032527; P:protein exit from endoplasmic reticulum; ISS:FlyBase.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR23287; RUBY-EYE2-LIKE PROTEIN; 1.
DR PANTHER; PTHR23287:SF16; TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..710
FT /note="WD repeat-containing protein CG11141"
FT /id="PRO_0000351218"
FT REPEAT 31..70
FT /note="WD 1"
FT REPEAT 133..172
FT /note="WD 2"
FT REGION 283..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 488
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 553
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
SQ SEQUENCE 710 AA; 79070 MW; 2B5A7CCECF8E4C71 CRC64;
MASSKELCSI REWAPLTEVI ERIPARLQRG FFPANLNLTC VDATEEFLAM GSDAGIVFWY
NRHTGEMQKL KAEVATRITC VRVVNSVEYM VAAGCANGQV SIFQIQKELP RDLDLVAPCT
KSRPIERYTI RDLHKCVVSC CEWSKNGMKL YSGDRQGVVV LTELDYQAHL SKSVEILSEA
YEIVQLSVRQ SYLLVATLYR CIVCQMDAQT SQWNITQVGK KDRKQLIDCG AIFLKKQEAN
KPQLVCGRPG LRFWVADAAG NVSKTVIFRD AVLRSPTWEI PILNPKQRSE PSGTHHTSAS
TSSTRHSGLA DGDVGYVASS NFRQLYLYDG HDSLLVTHDD ATLYVLNLDR LKVEAVARGL
RKILDFCVCG KEIFVLEGNR TLLRLAPLPE PPNKTAKVIF NPLMPPPVPV LGSHLSQLES
PIELQAEPVL QNAEECFELS PVEQLNLNVP IEIAVESPLT QQNRRLEIFR RIGEMDFEQS
IVHTTRKTSV GKPPEASGVG IVEIGHETHE LRLPLTNAAT LMEASYCQME NNGLASPLDM
KAAFLQHLPD ALSPTTLQKT VAEKAKTLAA ELDLPEVHLA PLSQEELHAV QAQTPQISDP
LIRCYPTHLE EASIQTSSRE NATNPADDYH VGEPVDGIRS FGVSKRKMAP LKFVLSQPKP
TLKLEENRDD EEYTSFLPDF RRAGDPLAIH KETPATSDSN TSSEWEFLDN
//
