ID Q6NTQ9_XENLA Unreviewed; 351 AA.
AC Q6NTQ9;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial {ECO:0000256|ARBA:ARBA00017279, ECO:0000256|PIRNR:PIRNR000543};
GN Name=ndufa10.S {ECO:0000313|RefSeq:NP_001084640.1,
GN ECO:0000313|Xenbase:XB-GENE-949141};
GN Synonyms=CI-42k {ECO:0000313|RefSeq:NP_001084640.1}, CI-42KD
GN {ECO:0000313|RefSeq:NP_001084640.1}, ndufa10
GN {ECO:0000313|RefSeq:NP_001084640.1,
GN ECO:0000313|Xenbase:XB-GENE-949141}, ndufa10-a
GN {ECO:0000313|RefSeq:NP_001084640.1}, ndufa10-b
GN {ECO:0000313|RefSeq:NP_001084640.1}, ndufa10b
GN {ECO:0000313|EMBL:AAH68897.1, ECO:0000313|RefSeq:NP_001084640.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH68897.1};
RN [1] {ECO:0000313|RefSeq:NP_001084640.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH68897.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary {ECO:0000313|EMBL:AAH68897.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001084640.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|PIRNR:PIRNR000543}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRNR:PIRNR000543};
CC -!- SUBUNIT: Complex I is composed of 45 different subunits. This a
CC component of the hydrophobic protein fraction.
CC {ECO:0000256|ARBA:ARBA00011514}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|PIRNR:PIRNR000543}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA10 subunit family.
CC {ECO:0000256|ARBA:ARBA00008606, ECO:0000256|PIRNR:PIRNR000543}.
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DR EMBL; BC068897; AAH68897.1; -; mRNA.
DR RefSeq; NP_001084640.1; NM_001091171.1.
DR STRING; 8355.Q6NTQ9; -.
DR PaxDb; 8355-Q6NTQ9; -.
DR DNASU; 414598; -.
DR GeneID; 414598; -.
DR KEGG; xla:414598; -.
DR AGR; Xenbase:XB-GENE-949141; -.
DR CTD; 414598; -.
DR Xenbase; XB-GENE-949141; ndufa10.S.
DR OMA; MFRQGYI; -.
DR OrthoDB; 6357at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 414598; Expressed in muscle tissue and 20 other cell types or tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR CDD; cd02030; NDUO42; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR015828; NDUFA10.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF15; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000543; NADH_UQ_42KD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 2: Evidence at transcript level;
KW Electron transport {ECO:0000256|ARBA:ARBA00022982,
KW ECO:0000256|PIRNR:PIRNR000543};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRNR:PIRNR000543};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|PIRNR:PIRNR000543};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR000543};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660,
KW ECO:0000256|PIRNR:PIRNR000543};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR000543}.
FT DOMAIN 56..258
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
SQ SEQUENCE 351 AA; 40055 MW; E249744F83EE61C5 CRC64;
MFSSAASRGL RLTGRICTGN VAQIHISSRH SLLYGYWAYV FGERTTKRFG PNSKIITVDG
NLASGKGQLA KNLADRLGMR YFPEADEHYL DKTTGDGSIL PSKFNGSCSL EKFYDDPKCP
DGNSYRLQYW MYSVRLMQYS DALEHLLSTG QGAVLERSPF SDFVFLEAMY KNGFIRKQCI
DHYNEIKGNS IDEFLPPHLV IYVDVPAAEV HKKILEKGQT SEKKVALPYL QSIEDTYKNS
FLPQISENSE ILKYSGNEAH DVEKVVEDIE YLKFDKGPWP EQNDVTYHHL RMFVEDKDKV
ASLITVPSYI PEITIGASEY DSAYYQYRLL PGRKYAKGYN ADIGDKMIWL K
//
