ID Q6P9K2_MOUSE Unreviewed; 1707 AA.
AC Q6P9K2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=Zfhx3 protein {ECO:0000313|EMBL:AAH60729.1};
DE Flags: Fragment;
GN Name=Zfhx3 {ECO:0000313|EMBL:AAH60729.1, ECO:0000313|MGI:MGI:99948};
GN Synonyms=Atbf1 {ECO:0000313|MGI:MGI:99948};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH60729.1};
RN [1] {ECO:0000313|EMBL:AAH60729.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH60729.1};
RC TISSUE=Brain {ECO:0000313|EMBL:AAH60729.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; BC060729; AAH60729.1; -; mRNA.
DR PeptideAtlas; Q6P9K2; -.
DR AGR; MGI:99948; -.
DR MGI; MGI:99948; Zfhx3.
DR ChiTaRS; Zfhx3; mouse.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 4.
DR Gene3D; 1.10.10.60; Homeodomain-like; 4.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45891; ZINC FINGER HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR45891:SF4; ZINC FINGER HOMEOBOX PROTEIN 3; 1.
DR Pfam; PF00046; Homeodomain; 4.
DR SMART; SM00389; HOX; 4.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SMART; SM00451; ZnF_U1; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 4.
DR PROSITE; PS00027; HOMEOBOX_1; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 134..194
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 231..291
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 319..348
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 523..545
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 632..692
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 704..734
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 936..996
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 136..195
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 233..292
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 634..693
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 938..997
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 14..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1129..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1395..1457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1569..1707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..68
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..490
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1210
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1419..1433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1583..1600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1635..1663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAH60729.1"
SQ SEQUENCE 1707 AA; 186439 MW; DC34F64C60FBA5DA CRC64;
LPLQQLERFA KQYREHYDKL YPLRPQTPEP PPPPPPPPPP PLPTAPPQPA SAPAIPASAP
PITSPTIAPA QPSVPLTQLS MPMELPIFSP LMMQTMPLQT LPAQLPPQLG PVEPLPADLA
QLYQHQLNPT LLQQQNKRPR TRITDDQLRV LRQYFDINNS PSEEQIKEMA DKSGLPQKVI
KHWFRNTLFK ERQRNKDSPY NFSNPPITSL EELKIDSRPP SPEPQKQEYW GSKRSSRTRF
TDYQLRVLQD FFDANAYPKD DEFEQLSNLL NLPTRVIVVW FQNARQKARK NYENQGEGKD
GERRELTNDR YIRTSNLNYQ CKKCSLVFQR IFDLIKHQKK LCYKDEDEEG QDDSQNEDSM
DAMEILTPTS SSCSTPMPSQ AYSTPAPSAA AANTAPSAFL QLTAETDELA TFNSKAEASD
EKPKQADPPS AQPNQTQEKQ GQPKPEMQQQ LEQLEQKTNA PQPKLPQPAA PSLPQPPPQA
PPPQCPLPQS SPSPSQLSHL PLKPLHTSTP QQLANLPPQL IPYQCDQCKL AFPSFEHWQE
HQQLHFLSAQ NQFIHPQFLD RSLDMPFMLF DPSNPLLASQ LLSGAIPQIP ASSATSPSTP
TSTMNTLKRK LEEKASASPG ENDSGTGGEE PQRDKRLRTT ITPEQLEILY QKYLLDSNPT
RKMLDHIAHE VGLKKRVVQV WFQNTRARER KGQFRAVGPA QAHRRCPFCR ALFKAKTALE
AHIRSRHWHE AKRAGYNLTL SAMLLDCDGG LQMKGDIFDG TSFSHLPPSS SDGQGVPLSP
VSKTMELSPR TLLSPSSIKV EGIEDFESPS MSSVNLNFDQ TKLDNDDCSS VNTAITDTTT
GDEGNADNDS ATGIATETKS SAPNEGLTKA AMMAMSEYED RLSSGLVSPA PSFYSKEYDN
EGTVDYSETS SLADPCSPSP GASGSAGKSG DGGDRPGQKR FRTQMTNLQL KVLKSCFNDY
RTPTMLECEV LGNDIGLPKR VVQVWFQNAR AKEKKSKLSM AKHFGINQTS YEGPKTECTL
CGIKYSARLS VRDHIFSQQH ISKVKDTIGS QLDKEKEYFD PATVRQLMAQ QELDRIKKAN
EVLGLAAQQQ GMFDNAPLQA LNLPTTYPAL QGIPPVLLPG LNSPSLPGFT PANTALTSPK
PNLMGLPSTT VPSPGLPTSG LPNKPSSASL SSPTPAQATM AMAPQPPPQP QQPQPPVQQP
PPPPAAQQIP APQLTPQQQR KDKDGEKGKE KEKAHKGKGE PLPVPKKEKG EAPPAATATI
SAPLPAMEYA VDPAQLQALQ AALTSDPTAL LTSQFLPYFV PGFSPYYAPQ IPGALQSGYL
QPMYGMEGLF PYSPALSQAL MGLSPGSLLQ QYQQYQQSLQ EAIQQQQQQQ QQQQQQQQRQ
LQQQQQQQQQ KVQQQQQQQQ QPKASQTPVP QGPASPDKDP AKESPKPEEQ KNVPREVSPL
LPKPPEEPEA ESKSASADSL CDPFIVPKVQ YKLVCRKCQA GFGDEEAARS HLKSLCCFGQ
SVVNLQEMVL HVPTGSGGSG GGGGGSGGGG GSYHCLACES ALCGEEALSQ HLESALHKHR
TITRAARNAK EHPSLLPHSA CFPDPSTAST SQSAAHSNDS PPPPSAAPSS SASPHASRKS
WPPVGSRASA AKPPSFPPLS SSSTVTSSSC STSGVQPSMP TDDYSEESDT DLSQKSDGPA
SPVEGPKDPS CPKDSGLTSV GTDTFRL
//
