ID Q6PFP9_DANRE Unreviewed; 740 AA.
AC Q6PFP9;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=Mitofusin-1 {ECO:0000313|EMBL:AAH57468.1, ECO:0000313|RefSeq:NP_956941.1};
GN Name=mfn1b {ECO:0000313|RefSeq:NP_956941.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1553};
GN Synonyms=mfn1 {ECO:0000313|EMBL:AAH57468.1}, zgc:66150
GN {ECO:0000313|RefSeq:NP_956941.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH57468.1};
RN [1] {ECO:0000313|EMBL:AAH57468.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:AAH57468.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_956941.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19584314;
RA Liesa M., Palacin M., Zorzano A.;
RT "Mitochondrial dynamics in mammalian health and disease.";
RL Physiol. Rev. 89:799-845(2009).
RN [3] {ECO:0000313|RefSeq:NP_956941.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22814267;
RA Lagman D., Sundstrom G., Ocampo Daza D., Abalo X.M., Larhammar D.;
RT "Expansion of transducin subunit gene families in early vertebrate
RT tetraploidizations.";
RL Genomics 100:203-211(2012).
RN [4] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_956941.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23516612;
RA Rahn J.J., Stackley K.D., Chan S.S.;
RT "Opa1 is required for proper mitochondrial metabolism in early
RT development.";
RL PLoS ONE 8:e59218-e59218(2013).
RN [6] {ECO:0000313|RefSeq:NP_956941.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [7] {ECO:0000313|RefSeq:NP_956941.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27086301; DOI=10.1007/s00128-016-1798-3;
RA Garcia-Reyero N., Escalon L., Prats E., Faria M., Soares A.M., Raldua D.;
RT "Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon
RT Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes.";
RL Bull. Environ. Contam. Toxicol. 96:707-713(2016).
RN [8] {ECO:0000313|RefSeq:NP_956941.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26926452; DOI=10.1038/srep22360;
RA Masuda T., Wada Y., Kawamura S.;
RT "ES1 is a mitochondrial enlarging factor contributing to form mega-
RT mitochondria in zebrafish cones.";
RL Sci. Rep. 6:22360-22360(2016).
RN [9] {ECO:0000313|RefSeq:NP_956941.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [10] {ECO:0000313|RefSeq:NP_956941.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30718751;
RA Park K.H., Ye Z.W., Zhang J., Hammad S.M., Townsend D.M., Rockey D.C.,
RA Kim S.H.;
RT "3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic
RT injury in zebrafish.";
RL Sci. Rep. 9:1138-1138(2019).
RN [11] {ECO:0000313|RefSeq:NP_956941.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
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DR EMBL; BC057468; AAH57468.1; -; mRNA.
DR RefSeq; NP_956941.1; NM_200647.1.
DR GeneID; 393620; -.
DR KEGG; dre:393620; -.
DR AGR; ZFIN:ZDB-GENE-040426-1553; -.
DR CTD; 393620; -.
DR ZFIN; ZDB-GENE-040426-1553; mfn1b.
DR OrthoDB; 3282693at2759; -.
DR PhylomeDB; Q6PFP9; -.
DR Proteomes; UP000000437; Chromosome 11.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0008053; P:mitochondrial fusion; IBA:GO_Central.
DR GO; GO:0051646; P:mitochondrion localization; IBA:GO_Central.
DR CDD; cd09912; DLP_2; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR006884; Fzo/mitofusin_HR2.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027094; Mitofusin_fam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10465:SF2; MITOFUSIN-1; 1.
DR PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF04799; Fzo_mitofusin; 1.
DR SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6PFP9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 73..317
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 380..407
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 740 AA; 84270 MW; 5BC47B8A5374E950 CRC64;
MEQLDPSPLK RFVLAKKKIS EVFEQLLVYV QEGCEFVKET CANESLENIA NKDQLDEIES
YTSKLSIIQE VLARRHMKVA FFGRTSNGKS TVINAMLRDR VLPSGIGHTT NCFLSVEGTD
EDKAFLKTEG SEEEKSIKTV NQLAHALHMD ESLDAGCLVK VFWPKTKCAL LRDDLVLVDS
PGTDVTTELD SWIDKFCLDA DVFVLVANSE STLMNTEKHF FHKVNEKLSK PNIFVLNNRW
DASAAEPEYM EDVRKQHTDR CVNFLVEELK VVDRAQAPNR IFFVSAKEVL NSRMQRAQGG
ALAEGFQDRL KEFQNFERSF EECISHSAVK TKFEQHTIRA KQITETVKDI MDQINITAAE
KRVVSLEERE YLIDRLDFVR NQLNLLIQDI KKKIKAITEE VENKVSNAMA EEICRLSVII
DEFRSDFHPS PQMLKMYKSD LLSHIEQGMG KNLAFRCSDA VNASVQCSQQ DMIECLKPLL
PSAAQTQLHM LIPSRKFELS YDLNCATLCS DFQENIEFQF SLGWSALVHR FLGPVNAKRA
LMLVDQNLQL TAPTTPTAPA VVQSQNSRAL GQNQASVTQE ELMLTMVNNL ASVTSRTSMS
VIIVGGVVWR TVGWRLIALS MSMYGLLYLY ERLTWTTKAK ERALKKQFVD YATEKLQMII
SFTSSNCSHQ VQQEIASTFA RLCQQVDITQ KDLESDIQRL TDKIQKLETV QNRSKVLRHK
ATALEMQLED FSSQYLRLQP
//
