ID Q6PQM1_HAPBU Unreviewed; 483 AA.
AC Q6PQM1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Type 3 somatostatin receptor {ECO:0000313|EMBL:AAS97963.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|EMBL:AAS97963.1};
RN [1] {ECO:0000313|EMBL:AAS97963.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16887916; DOI=10.1210/en.2006-0511;
RA Trainor B.C., Hofmann H.A.;
RT "Somatostatin regulates aggressive behavior in an African cichlid fish.";
RL Endocrinology 147:5119-5125(2006).
RN [2] {ECO:0000313|EMBL:AAS97963.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17374406; DOI=10.1016/j.bbr.2007.02.014;
RA Trainor B.C., Hofmann H.A.;
RT "Somatostatin and somatostatin receptor gene expression in dominant and
RT subordinate males of an African cichlid fish.";
RL Behav. Brain Res. 179:314-320(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AY585719; AAS97963.1; -; mRNA.
DR RefSeq; NP_001302470.1; NM_001315541.1.
DR AlphaFoldDB; Q6PQM1; -.
DR GeneID; 102297381; -.
DR CTD; 6753; -.
DR OrthoDB; 5393360at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004994; F:somatostatin receptor activity; IEA:InterPro.
DR CDD; cd15972; 7tmA_SSTR3; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000586; Somatstn_rcpt.
DR InterPro; IPR001856; Somatstn_rcpt_3.
DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1.
DR PANTHER; PTHR24229:SF42; SOMATOSTATIN RECEPTOR TYPE 3; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00246; SOMATOSTATNR.
DR PRINTS; PR00589; SOMATOSTTN3R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 64..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..329
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 353..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 53534 MW; FB44605D87AC4670 CRC64;
MGDTTYSGLE MTAETWENGS FASPSPGLPL FPLMFNDSDL NDTLFNSTNS TAPDAFSGPS
VAGVLIPLIY IIVCIIGLGG NTLVIHIVLH YSKIESVTNI YILNLAIADE LFMLGLPFLA
VQNTLQSWPF GSFMCRLVMT VDSINQFTSI FCLTVMSIDR YLAVVHPIRS SKWRRPQVAK
VVNGTVWALS FLVVLPVVIF ANIQKAGGTC NIAWPQPANI WRAAFIIYTS TVGFFCPLLI
ICLCYLLIVF KIRSSGKKVH ATSTKRRKSE RKVTRMVVIV VAVFVFCWLP FYALNIINLL
VALPPEYQGL YYFVVVLGYA NSCANPIVYG FLSDNFKRGF RKALCRSTRK VENHEPLEHQ
QQDEGRRALM PRESLRRAIR DEEDDDEEVV SEVTEIYRIA QNGNSSYQLQ SSQPLSLEKG
ATPGVTELAS PDRRDNMGDA KGKDANGATL TVPLLLNGTK GGSTKTLPEE NLEPSASLEI
SYL
//
