ID Q6QSR6_9HIV1 Unreviewed; 340 AA.
AC Q6QSR6;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:AAS47102.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAS47102.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAS47102.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAS47102.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A0042 {ECO:0000313|EMBL:AAS47102.1};
RX PubMed=15097303; DOI=10.1097/00126334-200405010-00008;
RG Adult ACTG Protocol 306 370 Teams;
RA Kuritzkes D.R., Bassett R.L., Hazelwood J.D., Barrett H., Rhodes R.A.,
RA Young R.K., Johnson V.A.;
RT "Rate of thymidine analogue resistance mutation accumulation with
RT zidovudine- or stavudine-based regimens.";
RL J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 36:600-603(2004).
CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC {ECO:0000256|RuleBase:RU004064}.
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DR EMBL; AY527859; AAS47102.1; -; Genomic_DNA.
DR MEROPS; A02.001; -.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd05482; HIV_retropepsin_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR034170; Retropepsin-like_cat_dom.
DR InterPro; IPR018061; Retropepsins.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF5; RIBONUCLEASE H; 1.
DR Pfam; PF00077; RVP; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU004064};
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|RuleBase:RU004064};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 17..86
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 140..330
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAS47102.1"
FT NON_TER 340
FT /evidence="ECO:0000313|EMBL:AAS47102.1"
SQ SEQUENCE 340 AA; 38739 MW; 66162C6B6A56DBBF CRC64;
TLWQRPLVTI KIGGQLKEAL LDTGADDTVL EDMNLPGXWK PKMIGGIGGF IKVRQYDQIP
IEICGHKAIG TVLVGPTPVN IIGRNLLTQI GCTLNFXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXCTELEKE GKISKIGPEN PYNTPVFAIK KKDSTKWRKL VDFRELNKRT
QDFWEVQLGI PHPAGLKKKK SVTVLDVGDA YFSVPLDKDF RKYTAFTIPS INNETPGIRY
QYNVLPQGWK GSPAIFQSSM TKILEPFRKQ NSDIVIYQYV DDLYVGSDLE IGQHRAKIEE
LRQHLLKWGF YTPDKKHQKE PPFLWMGYEL HPDKWTVQPI
//
