ID   Q6QTS9_9HIV1            Unreviewed;       246 AA.
AC   Q6QTS9;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:AAS19063.1};
DE   Flags: Fragment;
GN   Name=RT {ECO:0000313|EMBL:AAS19063.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAS19063.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAS19063.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=In23rt {ECO:0000313|EMBL:AAS19063.1};
RX   PubMed=15585093; DOI=10.1089/aid.2004.20.1032;
RA   Deshpande A., Recordon-Pinson P., Deshmukh R., Faure M., Jauvin V.,
RA   Garrigue I., Lafon M.E., Fleury H.J.;
RT   "Molecular characterization of HIV type 1 isolates from untreated patients
RT   of Mumbai (Bombay), India, and detection of rare resistance mutations.";
RL   AIDS Res. Hum. Retroviruses 20:1032-1035(2004).
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DR   EMBL; AY525972; AAS19063.1; -; Genomic_RNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW   ECO:0000313|EMBL:AAS19063.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW   Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT   DOMAIN          44..234
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAS19063.1"
FT   NON_TER         246
FT                   /evidence="ECO:0000313|EMBL:AAS19063.1"
SQ   SEQUENCE   246 AA;  28512 MW;  7E2C7DD2EBC97D0A CRC64;
     PISPIETVPV KLKPGMDGPK VKQWPLSEEK IKALTAICDE MEKEGKITKI GPENPYNTPI
     FAIKKKDSTK WRKLVDFREL NKRTQDFWEV QLGIPHPAGL KKKKSVTVLD VGDAYFSVPL
     YEDFRKYTAF TIPSINNETP GIRYQYNVLP QGWKGSPAIF QSSMTKILEP FRAQNPDLVI
     YQYMDDLYVG SDLEIGQHRA KIEELRNHLL KWGFTTPDKK HQKEPPFLWM GYELHPDKWT
     VQPIQL
//