ID Q6R313_RHEPA Unreviewed; 391 AA.
AC Q6R313;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Aloesone synthase {ECO:0000313|EMBL:AAS87170.1};
GN Name=ALS {ECO:0000313|EMBL:AAS87170.1};
OS Rheum palmatum (Chinese rhubarb).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC Caryophyllales; Polygonaceae; Polygonoideae; Rumiceae; Rheum.
OX NCBI_TaxID=137221 {ECO:0000313|EMBL:AAS87170.1};
RN [1] {ECO:0000313|EMBL:AAS87170.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15044020; DOI=10.1016/S0014-5793(04)00230-3;
RA Abe I., Utsumi Y., Oguro S., Noguchi H.;
RT "The first plant type III polyketide synthase that catalyzes formation of
RT aromatic heptaketide.";
RL FEBS Lett. 562:171-176(2004).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|RuleBase:RU003633}.
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DR EMBL; AY517486; AAS87170.1; -; mRNA.
DR AlphaFoldDB; Q6R313; -.
DR SMR; Q6R313; -.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF109; CHALCONE SYNTHASE 3-RELATED; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 2: Evidence at transcript level;
KW Acyltransferase {ECO:0000256|RuleBase:RU003633};
KW Transferase {ECO:0000256|RuleBase:RU003633}.
FT DOMAIN 6..228
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 239..389
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 165
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 391 AA; 43345 MW; 14A1E48CF703B59A CRC64;
MADVLQEIRN SQKASGPATV LAIGTAHPPT CYPQADYPDF YFRVCKSEHM TKLKKKMQFI
CDRSGIRQRF MFHTEENLGK NPGMCTFDGP SLNARQDMLI MEVPKLGAEA AEKAIKEWGQ
DKSRITHLIF CTTTSNDMPG ADYQFATLFG LNPGVSRTMV YQQGCFAGGT VLRLVKDIAE
NNKGARVLVV CSEIVAFAFR GPHEDHIDSL IGQLLFGDGA AALVVGTDID ESVERPIFQI
MSATQATIPN SLHTMALHLT EAGLTFHLSK EVPKVVSDNM EELMLEAFKP LGITDWNSIF
WQVHPGGRAI LDKIEEKLEL TKDKMRDSRY ILSEYGNLTS ACVLFVMDEM RKRSFREGKQ
TTGDGYEWGV AIGLGPGLTV ETVVLRSVPI P
//
