ID   Q6RKH8_GIBZA            Unreviewed;       412 AA.
AC   Q6RKH8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   08-NOV-2023, entry version 68.
DE   SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AAS57287.1};
DE   Flags: Fragment;
GN   Name=PKS2 {ECO:0000313|EMBL:AAS57287.1};
OS   Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=5518 {ECO:0000313|EMBL:AAS57287.1};
RN   [1] {ECO:0000313|EMBL:AAS57287.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GZ-3639 {ECO:0000313|EMBL:AAS57287.1};
RX   PubMed=14676319; DOI=10.1073/pnas.2532165100;
RA   Kroken S., Glass N.L., Taylor J.W., Yoder O.C., Turgeon B.G.;
RT   "Phylogenomic analysis of type I polyketide synthase genes in pathogenic
RT   and saprobic ascomycetes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:15670-15675(2003).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982}.
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DR   EMBL; AY495627; AAS57287.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6RKH8; -.
DR   PHI-base; PHI:729; -.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00098; THIOLASE_1; 1.
PE   3: Inferred from homology;
FT   DOMAIN          1..412
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAS57287.1"
FT   NON_TER         412
FT                   /evidence="ECO:0000313|EMBL:AAS57287.1"
SQ   SEQUENCE   412 AA;  44819 MW;  A12422D49C66842B CRC64;
     AIVGYSFKLP QGVEDDDAFW DVLENRRNLM TDWPESRVKT DSFANNKHQK WNGKGGHFIN
     DDVAAFDAPF FSLTAKEASA MDPMQRWTLE ATYHAFENAC LPVDSLKGSR TAVFSASMLE
     DYCRVTAVDP DNLERTAVTG SIVSCIIPNR VSWYFDLRGP SINVNNACSS SLLAVDMACK
     ALNSGDALCA VVTGTNLLLD PSIFQVLANQ GFLSPDGVCY SFDERANGYA RGEGVIAVVL
     KPVQAAIENG DMIRAVIRSI GSNQDGHTPI LTQPSSQSQE ELIRHVYKQA GLSMSDTRYV
     EAHGTGTPVG DPIEVKAIGR CFQEHRSHSE PLYVGSVKAN IGHLEGASAL ASLVKCICNL
     EKGVILPNAL LQKMNPAMNA DTYSIEVSTN PECPVASARS PPRISQLFRV RR
//