ID   Q6RYF8_HALRU            Unreviewed;       730 AA.
AC   Q6RYF8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Macrophage expressed protein {ECO:0000313|EMBL:AAR82936.1};
DE   Flags: Precursor;
OS   Haliotis rufescens (California red abalone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Vetigastropoda; Lepetellida; Haliotoidea; Haliotidae; Haliotis.
OX   NCBI_TaxID=6454 {ECO:0000313|EMBL:AAR82936.1};
RN   [1] {ECO:0000313|EMBL:AAR82936.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mantle {ECO:0000313|EMBL:AAR82936.1};
RX   PubMed=15020241; DOI=10.1016/j.bbrc.2004.02.073;
RA   Mah S.A., Moy G.W., Swanson W.J., Vacquier V.D.;
RT   "A perforin-like protein from a marine mollusk.";
RL   Biochem. Biophys. Res. Commun. 316:468-475(2004).
RN   [2] {ECO:0000313|EMBL:AAR82936.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mantle {ECO:0000313|EMBL:AAR82936.1};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AY485641; AAR82936.1; -; mRNA.
DR   AlphaFoldDB; Q6RYF8; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd22579; MPEG1_P2; 1.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR039707; MPEG1.
DR   PANTHER; PTHR31463:SF1; EPG-6; 1.
DR   PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..730
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004279676"
FT   TRANSMEM        666..691
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..352
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
SQ   SEQUENCE   730 AA;  79498 MW;  F6BF8B9C5833F31A CRC64;
     MLCFVFGVSI VAGVIGGELL NTVQKPEFPK GDVRACYGDN KKLERFEVLP GQGWDNLRNV
     DAGLVVVYNY SRCRTTEDGR FLIPDTVNTI PLKASKLNVY AELISHWSNY TSTTAHGVNI
     DAGLKFGSVK VSGTFSSGYE SVKSKQIGDK SYTTRVQLRY VRYSAKLQPD AALHPTFKSR
     LLSIAGSLQL NKTDQARYDS ELLVRDFGTH VVTSVDAGAA LVQEDQVSSE FVNSRKFTKN
     QITAGASASF LGIFSIDVSY HSSTSNEVKT AYEKSRSSSQ IDTLGGPMFK ASNFTANDWT
     NEVDHELVAV DRSGDPLFFL INSASLPELP NSVLYQLQNL VEETILHYYE FNTYRGCTEL
     DSPNFSPAAN LDDGTCKSPY TNLTFGGVYQ TCSMSSGSNN GDLCSGLDQV NPKTGGHTCP
     DGYESVELHT GRLSDSKSVH SCHSCWLFFK CCHDNYYHSE ATYIMHWCAA TGPVSQDSGY
     LFGGLYTSQL NNPLTQGKTC PVNFYTRTLG KDLHICISDD YELGMKYSMP FGGFISCTTG
     NPLAMNPKPK SKGDMNSALP SLHSFFQGSK TWPKHCPKGY SQHLAYVDQG CEINYCLLAG
     SLSEVGLPKI RRPPFQTAPL LLPSTENHVV FDPVTLTWRK NQEAMQFISA RGGDATSSST
     GSGMSAGAAA GIAVVATLGC VVISTIIIVL IKRRRKSSAG YRHLAIDDPL LSSQSNYGAT
     GSDAVNVNVE
//