ID Q6SNX2_CAEV Unreviewed; 376 AA.
AC Q6SNX2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:AAR22680.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAR22680.1};
OS Small ruminant lentivirus.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus;
OC Caprine arthritis encephalitis virus.
OX NCBI_TaxID=254355 {ECO:0000313|EMBL:AAR22680.1};
RN [1] {ECO:0000313|EMBL:AAR22680.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14967484; DOI=10.1016/j.virol.2003.09.047;
RA Shah C., Boni J., Huder J.B., Vogt H.R., Muhlherr J., Zanoni R.,
RA Miserez R., Lutz H., Schupbach J.;
RT "Phylogenetic analysis and reclassification of caprine and ovine
RT lentiviruses based on 104 new isolates: evidence for regular sheep-to-goat
RT transmission and worldwide propagation through livestock trade.";
RL Virology 319:12-26(2004).
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DR EMBL; AY454263; AAR22680.1; -; Genomic_DNA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd07557; trimeric_dUTPase; 1.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 2.70.40.10; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR033704; dUTPase_trimeric.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00692; dUTPase; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00665; rve; 1.
DR SUPFAM; SSF51283; dUTPase-like; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022750};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 149..190
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 191..351
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAR22680.1"
FT NON_TER 376
FT /evidence="ECO:0000313|EMBL:AAR22680.1"
SQ SEQUENCE 376 AA; 42913 MW; 26A0F3270B64BDF6 CRC64;
QNEEIDRYIS EVFLAKEGEG ILPKREEDAG YDLICPEEVI IGPGQVKRVP IDLKVNLKEK
QWAMIASKSS MAAKGVFTQG GIIDSGYQGQ IQVIVYNSNK VEVVIPQGRK FAQLILMNKI
HEELESWGRN RKTERGTKGF GSTGIYWIEN IPLAEEDHTK WHQDARSLHL EFEIPRTAAE
DIVNQCEICQ EERTPSVSRG GNKRGVDHWQ VDYTHYENNI LLVWVETNSG LIYAEKVKGE
SGQEFRTKVM QWYALFSPES LQSDNGPAFT AEPTQLLMKY LGVKHTTGIP WNPQSQAMVE
RAHQLLKSTL KKFQPQFIAI ESAMAAALVA INIKRKGGLG TSPMDIFIYN KEQKRINTKY
NKNSEKIQFC YYRIRK
//
