ID Q6SNY9_CAEV Unreviewed; 377 AA.
AC Q6SNY9;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:AAR22663.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAR22663.1};
OS Small ruminant lentivirus.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus;
OC Caprine arthritis encephalitis virus.
OX NCBI_TaxID=254355 {ECO:0000313|EMBL:AAR22663.1};
RN [1] {ECO:0000313|EMBL:AAR22663.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14967484; DOI=10.1016/j.virol.2003.09.047;
RA Shah C., Boni J., Huder J.B., Vogt H.R., Muhlherr J., Zanoni R.,
RA Miserez R., Lutz H., Schupbach J.;
RT "Phylogenetic analysis and reclassification of caprine and ovine
RT lentiviruses based on 104 new isolates: evidence for regular sheep-to-goat
RT transmission and worldwide propagation through livestock trade.";
RL Virology 319:12-26(2004).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY454246; AAR22663.1; -; Genomic_DNA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd07557; trimeric_dUTPase; 1.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 2.70.40.10; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR033704; dUTPase_trimeric.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00692; dUTPase; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00665; rve; 1.
DR SUPFAM; SSF51283; dUTPase-like; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022750};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 149..190
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 199..351
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAR22663.1"
FT NON_TER 377
FT /evidence="ECO:0000313|EMBL:AAR22663.1"
SQ SEQUENCE 377 AA; 42961 MW; 0DC083CE0B583AE6 CRC64;
QNEEIDKYIS DIFLAKEGKG IMEKRTEDAG YDLVCPQEVV IPAGKVKRIA IDLRLNLKRN
QWAMIGTKSS FASKGVFIQG GIIDSGYQGT IQVVVYNSND VEVVIPQGRK FAQLILMPLI
HEELEPWGET RKTERGIRGF GSTGAYWIEN IPKAEEDHDK WHQDATSLQV DYGIPKAAAE
EIVRHCEVCQ ENKMASTRRG GNKRGVDHWQ VDYTHYEDKI ILVWVETNSG LMYAEKVKGE
TGQEFRTHTM KWYALFAPKS LQSDNGPAFV AEPTQLLMKY LKVEHTTGVP WNPQSQALVE
RAHQTLKHTL EKFIPMFVVF ESALAAALIA LNIKRKGGLG TSPMDIFIFN KEQQRIQQQA
NNLNQSKIRF CYYRVRK
//
