ID Q6SZ59_CERAT Unreviewed; 350 AA.
AC Q6SZ59;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=T-cell surface antigen CD2 {ECO:0000256|ARBA:ARBA00021368};
GN Name=CD2 {ECO:0000313|EMBL:AAR15885.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|EMBL:AAR15885.1};
RN [1] {ECO:0000313|EMBL:AAR15885.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15302161; DOI=10.1016/j.molimm.2004.05.004;
RA Damschroder M.M., Kozhich A.A., Woods R.M., Cheng L., Mullikin B.A.,
RA Wilson S.D., Ulbrandt N.D., Bachy C.M., Wu H., Suzich J.A., Kiener P.A.,
RA Dall'Acqua W.F., White W.I.;
RT "Analysis of human and primate CD2 molecules by protein sequence and
RT epitope mapping with anti-human CD2 antibodies.";
RL Mol. Immunol. 41:985-1000(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AY445038; AAR15885.1; -; mRNA.
DR RefSeq; NP_001295266.1; NM_001308337.1.
DR AlphaFoldDB; Q6SZ59; -.
DR GeneID; 105596319; -.
DR CTD; 914; -.
DR OrthoDB; 4584733at2759; -.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd12087; TM_EGFR-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR015632; CD2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008424; Ig_C2-set.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR12080; SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE; 1.
DR PANTHER; PTHR12080:SF54; T-CELL SURFACE ANTIGEN CD2; 1.
DR Pfam; PF05790; C2-set; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01870; CD2ANTIGEN.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..350
FT /note="T-cell surface antigen CD2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004280916"
FT TRANSMEM 209..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..125
FT /note="Immunoglobulin V-set"
FT /evidence="ECO:0000259|Pfam:PF07686"
FT DOMAIN 134..204
FT /note="Immunoglobulin C2-set"
FT /evidence="ECO:0000259|Pfam:PF05790"
FT REGION 253..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..292
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 350 AA; 39493 MW; 621C74BC81D8C95D CRC64;
MSFPCKFVAS FLLIFNVSSK GAVSKEIRNA LETWGALGQD IDLDIPSFQM SDDIDDIRWE
KTSDKKKIAQ FRKEKTFEEK DTYKLFKNGT LKIKHLKIHD QDSYKVSIYD TNGKNVLEKT
FDLKIQERVS KPKISWTCIN TTLICEVMNG TDPELNLYQD GKHLKLSQRV ITHKWTTNLS
AKFKCTAGNK VSKESRVETV SCTEKGLDIY LIIGICGGGS LLMVFVTLLV FYITKRKKQR
SRRNDEELEI RAHRAATEER GRKPHQIPAS TPQNPAASQH PPPPPGHRSQ APSHRPLPPG
HRVQHQPQKR PPAPSGTQVH QQKGPPLPRP RVQPKPPQGA AENSLSPSSN
//
