ID   Q6T275_APLPU            Unreviewed;       517 AA.
AC   Q6T275;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Ink toxin 3 {ECO:0000313|EMBL:AAR14187.1};
DE   Flags: Fragment;
OS   Aplysia punctata (Spotted sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=71498 {ECO:0000313|EMBL:AAR14187.1};
RN   [1] {ECO:0000313|EMBL:AAR14187.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=14765133;
RA   Butzke D., Machuy N., Thiede B., Hurwitz R., Goedert S., Rudel T.;
RT   "Hydrogen peroxide produced by Aplysia ink toxin kills tumor cells
RT   independent of apoptosis via peroxiredoxin I sensitive pathways.";
RL   Cell Death Differ. 11:608-617(2004).
RN   [2] {ECO:0000313|EMBL:AAR14187.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16153453; DOI=10.1016/j.toxicon.2005.06.005;
RA   Butzke D., Hurwitz R., Thiede B., Goedert S., Rudel T.;
RT   "Cloning and biochemical characterization of APIT, a new l-amino acid
RT   oxidase from Aplysia punctata.";
RL   Toxicon 46:479-489(2005).
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DR   EMBL; AY442283; AAR14187.1; -; mRNA.
DR   AlphaFoldDB; Q6T275; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR10742:SF342; AMINO_OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          34..509
FT                   /note="Amine oxidase"
FT                   /evidence="ECO:0000259|Pfam:PF01593"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAR14187.1"
SQ   SEQUENCE   517 AA;  58359 MW;  88D0CCFAD20939AC CRC64;
     DGICRNRRQC NREVCGSTYD VAVVGAGPGG ANSAYMLRDS GLDIAVFEYS DRVGGRLFTY
     QLPNTPDVNL EIGGMRFIEG AMHRLWRVIS ELGLTPKVFK EGFGKEGRQR FYLRGQSLTK
     KQVKSGDVPY DLSPEEKENQ GNLVEYYLEK LTGLKLNGGP LKREVALKLT VPDGRFLYDL
     SFDEAMDLVA SPEGKEFTRD THVFTGEVTL DASAVSLFDD HLGEDYYGSE IYTLKEGLSS
     VPQGLLQTFL DAADSNEFYP NSHLKALRRK TNGQYVLYFE PTTSKDGQTT INYLEPLQVV
     CAQRVILAMP VYALNQLDWN QLRNDRATQA YAAVRPIPAS KVFMTFDQPW WLENERKSWV
     TKSDALFSQM YDWQKSEASG DYILIASYAD GLKAQYLREL KNQGEDIPGS DPGYNQVTEP
     LKDTILDHLT EAYGVERDSI PEPVTAASQF WTDYPFGCGW ITWRAGFHFD DVISTMRRPS
     LKDEVYVVGA DYSWGLISSW IEGALETSEN VINDYFL
//