ID   Q6UB78_PIG              Unreviewed;        68 AA.
AC   Q6UB78;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   RecName: Full=Toll-like receptor 2 {ECO:0000256|ARBA:ARBA00017391};
DE   Flags: Fragment;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:AAQ75579.1};
RN   [1] {ECO:0000313|EMBL:AAQ75579.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xiao Z., Hyland K.A., Murtaugh M.P.;
RT   "Porcine toll-like receptor sequences.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC       bacterial lipoproteins and other microbial cell wall components.
CC       Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC       bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC       leading to NF-kappa-B activation, cytokine secretion and the
CC       inflammatory response (By similarity). May also promote apoptosis in
CC       response to lipoproteins. Forms activation clusters composed of several
CC       receptors depending on the ligand, these clusters trigger signaling
CC       from the cell surface and subsequently are targeted to the Golgi in a
CC       lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in
CC       response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to
CC       triacylated lipopeptides. {ECO:0000256|ARBA:ARBA00025293}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC       {ECO:0000256|ARBA:ARBA00004596}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004596}. Membrane raft
CC       {ECO:0000256|ARBA:ARBA00004285}.
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DR   EMBL; AY373816; AAQ75579.1; -; mRNA.
DR   AlphaFoldDB; Q6UB78; -.
DR   HOGENOM; CLU_006000_3_0_1; -.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR   Pfam; PF01582; TIR; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Receptor {ECO:0000313|EMBL:AAQ75579.1}.
FT   DOMAIN          1..68
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAQ75579.1"
FT   NON_TER         68
FT                   /evidence="ECO:0000313|EMBL:AAQ75579.1"
SQ   SEQUENCE   68 AA;  8154 MW;  B265CB3F82062A80 CRC64;
     DSIEKSQKTI FVLSENFVKS EWCKYELDFS HFRLFDENDD TAILILLEPI EKKAIPQRFC
     KLRKIMNT
//