ID Q6UYN2_9HIV1 Unreviewed; 868 AA.
AC Q6UYN2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAR00913.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAR00913.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAR00913.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14990699; DOI=10.1128/JVI.78.6.2790-2807.2004;
RA Kuhmann S.E., Pugach P., Kunstman K.J., Taylor J., Stanfield R.L.,
RA Snyder A., Strizki J.M., Riley J., Baroudy B.M., Wilson I.A., Korber B.T.,
RA Wolinsky S.M., Moore J.P.;
RT "Genetic and phenotypic analyses of human immunodeficiency virus type 1
RT escape from a small-molecule CCR5 inhibitor.";
RL J. Virol. 78:2790-2807(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; AY357560; AAR00913.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR HAMAP; MF_04083; HIV_ENV; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR037527; Gp160.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Clathrin-mediated endocytosis of virus by host
KW {ECO:0000256|ARBA:ARBA00022570};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AAR00913.1};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022570};
KW Virion {ECO:0000313|EMBL:AAR00913.1};
KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00022570}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..530
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 550..739
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 739..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAR00913.1"
SQ SEQUENCE 868 AA; 98908 MW; 856F254D61C8EFC5 CRC64;
MRVTGIRKNY QHLWRWGTML LWRWGTMLLG ILMICSAAGN LWVTVYYGVP VWKEATTTLF
CATDAKAYDT EVHNVWATHA CVPTDPNPQE VVLGNVTENF NMWKNNMVEQ MHEDIISLWD
QSLKPCVKLT PLCVTLNCTD YVKNITNNAT STNSSWGEPM EKGELKNCSF NITTSMRKVQ
KQYALFYKLD VVPIDNDSNN NDSTNTNYTN YRLISCNTSV ITQACPKVSF EPIPIHYCAP
AGFAILKCND KKFDGTGPCT NVSAVQCTHG IRPVVSTQLL LNGSLAEEEV IIRSENFTNN
AKTIMVQLNV SVEINCTRPN NNTRKRISMG PGRVYYTTGE IVGDIRKAHC NISRTQWNNT
LKHIVEKLGK QFGTNKTIFN HSSGGDPEIV MHSFNCGGEF FYCNSTKLFN STWTRNNDTW
TTERSNSTEE HITLPCRIKQ IINMWQEVGK AMYAPPIRGK IRCSSNITGL LLTRDGGNND
TRGTEIFRPG GGDMRDNWRS ELYKYKVVRI EPLGIAPTEA KRRVVQREKR AVGLIGAMFL
GFLGAAGSTM GAASVALTVQ ARQLLSGIVQ QQNNLLRAIE AQQHLLQLTV WGIKQLQARV
LAVERYLRDQ QLLGIWGCSG KIICTTAVPW NASWSNRSID EIWNNMTWME WEKEIDNYTG
LIYNLLEKSQ NQQEKNEQEL LALDKWANLW NWLDISNWLW YIKIFIMIVG GLVGLRIVFA
VLSIVNRVRQ GYSPLSFQTR LPAPRGPDRP EGIEEEGGER DRDRSVRLVD GFLALLRSLC
LFSYHRLRDL LWIVELLGRR GWEVLKYWWN LLQYWIQELK NSAISLLNAT AVAVAEGTDW
VLEVVQRACR AILHIPRRIR QGLERLLL
//
