ID   Q6XJ55_MRNV             Unreviewed;      1045 AA.
AC   Q6XJ55;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 2.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022412};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE   AltName: Full=RNA replicase {ECO:0000256|ARBA:ARBA00032757};
OS   Macrobrachium rosenbergii nodavirus (MrNV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Magsaviricetes;
OC   Nodamuvirales; Nodaviridae.
OX   NCBI_TaxID=222557 {ECO:0000313|EMBL:AAQ54758.2};
OH   NCBI_TaxID=79674; Macrobrachium rosenbergii (Giant fresh water prawn).
RN   [1] {ECO:0000313|EMBL:AAQ54758.2}
RP   NUCLEOTIDE SEQUENCE.
RA   Shi Z., Xie Y., Tang X., Qian D., Sri Widada J., Bonami J.R.;
RT   "Sequence comparison of two Macribrachium rosenbergii nodavirus isolates.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the nodaviridae RNA polymerase family.
CC       {ECO:0000256|ARBA:ARBA00007751}.
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DR   EMBL; AY231436; AAQ54758.2; -; Genomic_RNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   CDD; cd23173; ps-ssRNAv_Nodaviridae_RdRp; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043647; Noda_Vmethyltr_dom.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   Pfam; PF19222; Noda_Vmethyltr; 1.
DR   Pfam; PF00680; RdRP_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000313|EMBL:AAQ54758.2}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          103..245
FT                   /note="Nodavirus methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF19222"
FT   DOMAIN          597..748
FT                   /note="RNA-directed RNA polymerase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00680"
FT   REGION          879..1045
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        942..982
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        995..1013
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1045 AA;  118207 MW;  273E020708EEC14F CRC64;
     MKCSNLLYGV ELPMCLQSSM GMAVVTGLAI VYLVIYILIY SFTHGPRLSR RLASYVVIGP
     YEAIAKSRPA MALQRAMVDL TRRDVRTDWY PLNNLLMNKP HRLSENGHKT SGAVRDAARN
     LITSAITSLG MDKYEISPGG HTVDEQLASH RHYAVNDLHR ASADDAVKEN AVIVAIDTDY
     YLRDPSIYLS NNNPFILHTF QPITVAGKDG DVRFTISDNQ VDYRVDGGGR WQHKVWNWCD
     YGEFLIFKEH PRILSINWWL SFLGIRKVIY QKIQHARPWV DCPNRALVWG LPQFTSYMIT
     WLPIEMNARE LGRVNYQCAS RPGWNCLVDH TSTKLVASIG REGNDCHVEL AKEDLDVVLG
     LSTMQSVTSR LLQMGYKQPQ TLATVCQFYN SAAYDILSCS IVARPSQPPV HWPLASEIDQ
     PTTSFRNYSN NIVTCGNLCP QLKRWEVLSN SLEHRVTMVA NSKVPTPRIA RFAEEYVRLV
     VPEANVGVPY SLEDARKELD KPTQVNAVNQ IWETVDMEVR RLIEAFVKNE PTNKSGRIIS
     SFADSRFLLK FSTYTLAFRD EVLHAEHNQH WFCPGLTPNE IADKVCDYVR GVATPAEGDF
     SNFDGRVSAW CQENVMNAVY HRWFNRKFSK ELQKYTSMLV SCPARAKRFG FQYEPGVGVK
     SGSPTTCDLN SVLNNFTQYA AVRLTKPDLS PQEAFEQTGL SFGDDSLFDK QYQLRWNYVV
     EQLGMELKVE PFDPSNGVTF LARVFPDPYS TNTSFQDPLR TWRKLNMTSR TCVPVESAAL
     DRVSGYLVTD KYSPVTSEYC HMIERCYMNT AESVTRRRQR KDCDREKPYW LVSGGAWPQR
     EGDYELMMRV TAARTGFEES KLINLISQFQ SVHDPWDIKP LDYQEPSPYK DTLDVDGQPV
     DAVDDRQYQN ERNTVNLRAG AAISQMPVPS VPGGEDCNRQ SADMSGPKSS EGSEQLQGVP
     EQDGSNRLQC HRQPTIKVKG GSNTKGRSRK SRNGGRSISS KTANPTTHAV GGGNGKTRVT
     IAKRSRPKRP HDVVSNAWET LNDNR
//