ID Q6XPY3_XENLA Unreviewed; 109 AA.
AC Q6XPY3;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE RecName: Full=Transcription initiation factor IIA subunit 2 {ECO:0000256|PIRNR:PIRNR009415};
GN Name=gtf2a2.L {ECO:0000313|RefSeq:XP_018106243.1,
GN ECO:0000313|RefSeq:XP_018106244.1, ECO:0000313|RefSeq:XP_018106245.1,
GN ECO:0000313|RefSeq:XP_041442668.1,
GN ECO:0000313|Xenbase:XB-GENE-990828};
GN Synonyms=gtf2a2 {ECO:0000313|Xenbase:XB-GENE-990828}, gtf2a2.S
GN {ECO:0000313|RefSeq:XP_018110999.1,
GN ECO:0000313|Xenbase:XB-GENE-17330673}, TFIIAg
GN {ECO:0000313|EMBL:AAP44970.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAP44970.1};
RN [1] {ECO:0000313|EMBL:AAQ04073.1}
RP NUCLEOTIDE SEQUENCE.
RA Han S., DeJong J.;
RT "Xenopus laevis TFIIAg (xTFIIAg).";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAP44970.1}
RP NUCLEOTIDE SEQUENCE.
RA Han S., DeJong J.;
RT "Xenopus TFIIA small subunit (TFIIAg).";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAH88977.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH88977.1}, and Ovary
RC {ECO:0000313|EMBL:AAH72888.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:XP_018106243.1, ECO:0000313|RefSeq:XP_018106244.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018106243.1,
RC ECO:0000313|RefSeq:XP_018106244.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018106243.1,
RC ECO:0000313|RefSeq:XP_018106244.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- FUNCTION: TFIIA is a component of the transcription machinery of RNA
CC polymerase II and plays an important role in transcriptional
CC activation. {ECO:0000256|PIRNR:PIRNR009415}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR009415}.
CC -!- SIMILARITY: Belongs to the TFIIA subunit 2 family.
CC {ECO:0000256|ARBA:ARBA00007675, ECO:0000256|PIRNR:PIRNR009415}.
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DR EMBL; BC072888; AAH72888.1; -; mRNA.
DR EMBL; BC088977; AAH88977.1; -; mRNA.
DR EMBL; AY218796; AAP44970.1; -; mRNA.
DR EMBL; AF424778; AAQ04073.1; -; mRNA.
DR RefSeq; NP_001080922.1; NM_001087453.2.
DR RefSeq; XP_018106243.1; XM_018250754.2.
DR RefSeq; XP_018106244.1; XM_018250755.2.
DR RefSeq; XP_018106245.1; XM_018250756.2.
DR RefSeq; XP_018110998.1; XM_018255509.2.
DR RefSeq; XP_018110999.1; XM_018255510.2.
DR RefSeq; XP_018111000.1; XM_018255511.1.
DR RefSeq; XP_041442668.1; XM_041586734.1.
DR STRING; 8355.Q6XPY3; -.
DR PaxDb; 8355-Q6XPY3; -.
DR DNASU; 387523; -.
DR GeneID; 108712955; -.
DR GeneID; 387523; -.
DR KEGG; xla:108712955; -.
DR KEGG; xla:387523; -.
DR AGR; Xenbase:XB-GENE-17330673; -.
DR AGR; Xenbase:XB-GENE-990828; -.
DR CTD; 108712955; -.
DR CTD; 387523; -.
DR Xenbase; XB-GENE-990828; gtf2a2.L.
DR Xenbase; XB-GENE-17330673; gtf2a2.S.
DR OrthoDB; 5052738at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 108712955; Expressed in egg cell and 19 other cell types or tissues.
DR GO; GO:0005672; C:transcription factor TFIIA complex; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd10014; TFIIA_gamma_C; 1.
DR CDD; cd10145; TFIIA_gamma_N; 1.
DR Gene3D; 2.30.18.10; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR Gene3D; 1.10.287.190; Transcription factor IIA gamma subunit, alpha-helical domain; 1.
DR InterPro; IPR009083; TFIIA_a-hlx.
DR InterPro; IPR009088; TFIIA_b-brl.
DR InterPro; IPR003194; TFIIA_gsu.
DR InterPro; IPR015871; TFIIA_gsu_C.
DR InterPro; IPR015872; TFIIA_gsu_N.
DR PANTHER; PTHR10966; TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2; 1.
DR PANTHER; PTHR10966:SF0; TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2; 1.
DR Pfam; PF02751; TFIIA_gamma_C; 1.
DR Pfam; PF02268; TFIIA_gamma_N; 1.
DR PIRSF; PIRSF009415; Hum_TFIIA_gamma; 1.
DR SUPFAM; SSF47396; Transcription factor IIA (TFIIA), alpha-helical domain; 1.
DR SUPFAM; SSF50784; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
PE 2: Evidence at transcript level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR009415};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR009415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR009415}.
FT DOMAIN 3..48
FT /note="Transcription initiation factor IIA gamma subunit N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF02268"
FT DOMAIN 59..100
FT /note="Transcription initiation factor IIA gamma subunit C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF02751"
SQ SEQUENCE 109 AA; 12428 MW; 3B29AFC01334262B CRC64;
MAYQLYRNTT LGNSLQESLD ELIQSQQINP QLALQVLLQF DKAINSALAQ RVRNRVNFRG
SLNTYRFCDN VWTFVLNDVE FREVTDLVKV DKVKIVACDG KNTGSNTAE
//
