ID Q6XVM1_CHICK Unreviewed; 55 AA.
AC Q6XVM1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 95.
DE SubName: Full=Preproinsulin {ECO:0000313|EMBL:AAP45961.1};
DE Flags: Fragment;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAP45961.1};
RN [1] {ECO:0000313|EMBL:AAP45961.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15012953; DOI=10.1016/S1055-7903(03)00254-9;
RA Simon J., Laurent S., Grolleau G., Thoraval P., Soubieux D., Rasschaert D.;
RT "Evolution of preproinsulin gene in birds.";
RL Mol. Phylogenet. Evol. 30:755-766(2004).
RN [2] {ECO:0000313|EMBL:AAP45961.1}
RP NUCLEOTIDE SEQUENCE.
RA Simon J., Laurent S., Grolleau G., Thoraval P., Soubieux D., Rasschaert D.;
RT "Erratum to 'Evolution of preproinsulin gene in birds'.";
RL Mol. Phylogenet. Evol. 31:807-809(2004).
CC -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC cell permeability to monosaccharides, amino acids and fatty acids. It
CC accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC synthesis in liver. {ECO:0000256|ARBA:ARBA00002985}.
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DR EMBL; AY206817; AAP45961.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6XVM1; -.
DR SMR; Q6XVM1; -.
DR VEuPathDB; HostDB:geneid_396145; -.
DR HOGENOM; CLU_140421_1_0_1; -.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04367; IlGF_insulin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR004825; Insulin.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR PANTHER; PTHR11454:SF9; INSULIN; 1.
DR PANTHER; PTHR11454; INSULIN/INSULIN GROWTH FACTOR; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00277; INSULIN.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
PE 4: Predicted;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..55
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004282360"
FT DOMAIN 21..55
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAP45961.1"
FT NON_TER 55
FT /evidence="ECO:0000313|EMBL:AAP45961.1"
SQ SEQUENCE 55 AA; 5977 MW; 2DFA6B28914127F6 CRC64;
LPLLALLVFS GPGTSYAAAN QHLCGSHLVE ALYLVCGERG FFYSPKARRD VEQPL
//
