ID Q6ZQF2_MOUSE Unreviewed; 720 AA.
AC Q6ZQF2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
DE Flags: Fragment;
GN Name=Ncstn {ECO:0000313|MGI:MGI:1891700};
GN Synonyms=mKIAA0253 {ECO:0000313|EMBL:BAC97912.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC97912.1};
RN [1] {ECO:0000313|EMBL:BAC97912.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BAC97912.1};
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK129102; BAC97912.1; -; mRNA.
DR AlphaFoldDB; Q6ZQF2; -.
DR SwissPalm; Q6ZQF2; -.
DR AGR; MGI:1891700; -.
DR MGI; MGI:1891700; Ncstn.
DR ChiTaRS; Ncstn; mouse.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0043085; P:positive regulation of catalytic activity; ISS:UniProtKB.
DR GO; GO:0016485; P:protein processing; ISS:UniProtKB.
DR CDD; cd03881; M28_Nicastrin; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 681..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..234
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAC97912.1"
SQ SEQUENCE 720 AA; 79845 MW; 17B521757B4BFF45 CRC64;
KGPEASAQRR GKMATTRGGS GPDPGSRGLL LLFFSVVLAG LCGGNSVERK IYIPLNKTAP
CVRLLNATHQ IGCQSSISGD TGVIHVVEKE EDLKWVLTDG PNPPYMVLLE GKLFTRDVME
KLKGTTSRIA GLAVTLAKPN STSSFSPSVQ CPNDGFGIYS NSYGPEFAHC KKTLWNELGN
GLAYEDFSFP IFLLEDENET KVIKQCYQDH NLGQNGSAPS FPLCAMQLFS HMHAVISTAT
CMRRSFIQST FSINPEIVCD PLSDYNVWSM LKPINTSVGL EPDVRVVVAA TRLDSRSFFW
NVAPGAESAV ASFVTQLAAA EALHKAPDVT TLSRNVMFVF FQGETFDYIG SSRMVYDMEN
GKFPVRLENI DSFVELGQVA LRTSLDLWMH TDPMSQKNES VKNQVEDLLA TLEKSGAGVP
EVVLRRLAQS QALPPSSLQR FLRARNISGV VLADHSGSFH NRYYQSIYDT AENINVTYPE
WQSPEEDLNF VTDTAKALAN VATVLARALY ELAGGTNFSS SIQADPQTVT RLLYGFLVRA
NNSWFQSILK HDLRSYLDDR PLQHYIAVSS PTNTTYVVQY ALANLTGKAT NLTREQCQDP
SKVPNESKDL YEYSWVQGPW NSNRTERLPQ CVRSTVRLAR ALSPAFELSQ WSSTEYSTWA
ESRWKDIQAR IFLIASKELE FITLIVGFSI LIFSLIVTYC INAKADVLFV APREPGAVSY
//
