ID   Q6ZT73_HUMAN            Unreviewed;      1101 AA.
AC   Q6ZT73;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=cDNA FLJ44903 fis, clone BRAMY3005184, highly similar to Mus musculus ankyrin 3, epithelial (Ank3) {ECO:0000313|EMBL:BAC86721.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAC86721.1};
RN   [1] {ECO:0000313|EMBL:BAC86721.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Amygdala {ECO:0000313|EMBL:BAC86721.1};
RA   Oshima A., Takahashi-Fujii A., Tanase T., Imose N., Takeuchi K., Arita M.,
RA   Musashino K., Yuuki H., Hara H., Sugiyama T., Irie R., Otsuki T., Sato H.,
RA   Wakamatsu A., Ishii S., Yamamoto J., Isono Y., Kawai-Hio Y., Saito K.,
RA   Nishikawa T., Kimura K., Yamashita H., Matsuo K., Nakamura Y., Sekine M.,
RA   Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., Kanehori K., Sugiyama A.,
RA   Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K.,
RA   Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR   EMBL; AK126851; BAC86721.1; -; mRNA.
DR   AlphaFoldDB; Q6ZT73; -.
DR   PeptideAtlas; Q6ZT73; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd08803; Death_ank3; 1.
DR   Gene3D; 2.60.220.30; -; 2.
DR   Gene3D; 2.60.40.2660; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR037971; Ank3_Death.
DR   InterPro; IPR040745; Ankyrin_UPA.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24198:SF173; ANKYRIN-3; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF17809; UPA_2; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS51145; ZU5; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          219..374
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          376..523
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          712..796
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          859..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1049..1101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        859..873
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1063..1090
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1101 AA;  122189 MW;  321372D4C0A60856 CRC64;
     MSEEPKEKNA KPAHRKRKGK KSDANASYLR AARAGHLEKA LGYISVVDTL KIVTEETMTT
     TTVTEKHKMN VPETMNEVLD MSDDEVRKAN APEMLSDGEY ISDVEEGEDA MTGDTDKYLG
     PQDLKELGDD SLPAEGYMGF SLGARSASLR SFSSDRSYTL NRSSYARDSM MIEELLVPSK
     EQHLTFTREF DSDSLRHYSW AADTLDNVNL VSSPIHSGFL VSFMVDARGG SMRGSRHHGM
     RIIIPPRKCT APTRITCRLV KRHKLANPPP MVEGEGLASR LVEMGPAGAQ FLGPVIVEIP
     HFGSMRGKER ELIVLRSENG ETWKEHQFDS KNEDLTELLN GMDEELDSPE ELGKKRICRI
     ITKDFPQYFA VVSRIKQESN QIGPEGGILS STTVPLVQAS FPEGALTKRI RVGLQAQPVP
     DEIVKKILGN KATFSPIVTV EPRRRKFHKP ITMTIPVPPP SGEGVSNGYK GDTTPNLRLL
     CSITGGTSPA QWEDITGTTP LTFIKDCVSF TTNVSARFWL ADCHQVLETV GLATQLYREL
     ICVPYMAKFV VFAKMNDPVE SSLRCFCMTD DKVDKTLEQQ ENFEEVARSK DIEVLEGKPI
     YVDCYGNLAP LTKGGQQLVF NFYSFKENRL PFSIKIRDTS QEPCGRLSSL KEPKTTKGLP
     QTAVCNLNIT LPAHKKIEKT DRRQSFASLA LRKRYSYLTE PGMSPQSPCE RTDIRMAIVA
     DHLGLSWTEL ARELNFSVDE INQIRVENPN SLISQSFMLL KKWVTRDGKN ATTDALTSVL
     TKINRIDIVT LLEGPIFDYG NISGTRSFAD ENNVFHDPVD GYPSLQVELE TPTGLHYTPP
     TPFQQDDYFS DISSIESPLR TPSRLSDGLV PSQGNIEHSA DGPPVVTAED ASLEDSKLED
     SVPLTEMPEA VDVDESQLEN VCLSWQNETS SGNLESCAQA RRVTGGLLDR LDDSPDQCRD
     SITSYLKGEA GKFEANGSHT EITPEAKTKS YFPESQNDVG KQSTKETLKP KIHGSGHVEE
     PASPLAAYQK SLEETSKLII EETKPCVPVS MKKMSRTSPA DGKPRLSLHE EEGSSGSEQK
     GEGFKVKTKK EIRHVEKKSH S
//