ID Q703C1_HHV1 Unreviewed; 550 AA.
AC Q703C1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE RecName: Full=Envelope glycoprotein E {ECO:0000256|ARBA:ARBA00013988};
DE Flags: Fragment;
GN Name=US8 {ECO:0000313|EMBL:CAF24785.1};
OS Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha1.
OX NCBI_TaxID=10298 {ECO:0000313|EMBL:CAF24785.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:CAF24785.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=993626 {ECO:0000313|EMBL:CAF24785.1};
RX PubMed=15367642; DOI=10.1128/JVI.78.19.10755-10764.2004;
RA Norberg P.R., Bergstrom T., Kekabdar E., Lindh M., Liljeqvist J.A.;
RT "Phylogenetic analysis of clinical herpes simplex virus type 1 isolates
RT identified three genetic groups and recombinant viruses.";
RL J. Virol. 78:10755-10764(2004).
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I
CC membrane protein {ECO:0000256|ARBA:ARBA00004251}. Host cell junction
CC {ECO:0000256|ARBA:ARBA00004315}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein E family.
CC {ECO:0000256|ARBA:ARBA00008101}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ626498; CAF24785.1; -; Genomic_DNA.
DR RefSeq; YP_009137143.1; NC_001806.2.
DR SMR; Q703C1; -.
DR DNASU; 2703448; -.
DR GeneID; 2703448; -.
DR KEGG; vg:2703448; -.
DR OrthoDB; 11660at10239; -.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0044156; C:host cell junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR046463; Herpes_gE_N.
DR InterPro; IPR003404; Herpes_glycopE_Fc.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF02480; Herpes_gE; 1.
DR Pfam; PF20418; Herpes_gE_N; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
PE 3: Inferred from homology;
KW Host cell junction {ECO:0000256|ARBA:ARBA00023081};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT TRANSMEM 420..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..163
FT /note="Envelope glycoprotein E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF20418"
FT DOMAIN 220..392
FT /note="Envelope glycoprotein E Fc-binding"
FT /evidence="ECO:0000259|Pfam:PF02480"
FT REGION 162..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..211
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 550
FT /evidence="ECO:0000313|EMBL:CAF24785.1"
SQ SEQUENCE 550 AA; 59094 MW; BE8271E5B7E34776 CRC64;
MDRGAVVGFL LGVCVVSCLA GTPKTSWRRV SVGEDVSLLP APGPTGRGPT QKLLWAVEPL
DGCGPLHPSW VSLMPPKQVP ETVVDAACMR APVPLAMAYA PPAPSATGGL RTDFVWQERA
AVVNRSLVIH GVRETDSGLY TLSVGDIKDP ARQVASVVLV VQPAPVPTPP PTPADYDEDD
NDEGEDESLA GTPASGTPRL PPPPAPPRSW PSAPEVSHVR GVTVRMETPE AILFSPGETF
STNVSIHAIA HDDQTYSMDV VWLRFDVPTS CAEMRIYESC LYHPQLPECL SPADAPCAAS
TWTSRLAVRS YAGCSRTNPP PRCSAEAHME PVPGLAWQAA SVNLEFRDAS PQHSGLYLCV
VYVNDHIHAW GHITISTAAQ YRNAVVEQPL PQRGADLAEP THPHVGAPPH APPTHGALRL
GAVMGAALLL SALGLSVWAC MTCWRRRAWR AVKSRASGKG PTYIRVADSE LYADWSSDSE
GERDQVPWLA PPERPDSPST NGSGFEILSP TAPSVYPRSD GHQSRRQLTT FGSGRPDRRY
SQASDSSVFW
//