ID Q705N9_ARATH Unreviewed; 390 AA.
AC Q705N9;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Chalcone synthase {ECO:0000313|EMBL:CAF04430.1};
DE EC=2.3.1.74 {ECO:0000313|EMBL:CAI30400.1};
DE Flags: Fragment;
GN Name=chs {ECO:0000313|EMBL:CAF04430.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:CAF04430.1};
RN [1] {ECO:0000313|EMBL:CAF04430.1}
RP NUCLEOTIDE SEQUENCE.
RA Ramos-Onsins S.E., Stranger B.E., Mitchell-Olds T., Aguade M.;
RT "Multilocus analysis of variation and speciation in the closely-related
RT species Arabidopsis halleri and A. lyrata.";
RL Genetics 16:373-388(2003).
RN [2] {ECO:0000313|EMBL:CAI30400.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15705952; DOI=10.1105/tpc.104.027839;
RA de Meaux J., Goebel U., Pop A., Mitchell-Olds T.;
RT "Allele-specific assay reveals functional variation in the chalcone
RT synthase promoter of Arabidopsis thaliana that is compatible with neutral
RT evolution.";
RL Plant Cell 17:676-690(2005).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|RuleBase:RU003633}.
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DR EMBL; AJ619907; CAF04429.1; -; Genomic_DNA.
DR EMBL; AJ619908; CAF04430.1; -; Genomic_DNA.
DR EMBL; AJ619909; CAF04431.1; -; Genomic_DNA.
DR EMBL; AJ619911; CAF04433.1; -; Genomic_DNA.
DR EMBL; AJ619912; CAF04434.1; -; Genomic_DNA.
DR EMBL; AJ867820; CAI30400.1; -; Genomic_DNA.
DR EMBL; AJ867821; CAI30401.1; -; Genomic_DNA.
DR EMBL; AJ867822; CAI30402.1; -; Genomic_DNA.
DR EMBL; AJ867823; CAI30403.1; -; Genomic_DNA.
DR EMBL; AJ867824; CAI30404.1; -; Genomic_DNA.
DR EMBL; AJ867825; CAI30405.1; -; Genomic_DNA.
DR EMBL; AJ867826; CAI30406.1; -; Genomic_DNA.
DR EMBL; AJ867827; CAI30407.1; -; Genomic_DNA.
DR EMBL; AJ867828; CAI30408.1; -; Genomic_DNA.
DR EMBL; AJ867829; CAI30409.1; -; Genomic_DNA.
DR EMBL; AJ867830; CAI30410.1; -; Genomic_DNA.
DR EMBL; AJ867831; CAI30411.1; -; Genomic_DNA.
DR EMBL; AJ867832; CAI30412.1; -; Genomic_DNA.
DR EMBL; AJ867833; CAI30413.1; -; Genomic_DNA.
DR EMBL; AJ867834; CAI30414.1; -; Genomic_DNA.
DR EMBL; AJ867835; CAI30415.1; -; Genomic_DNA.
DR EMBL; AJ867836; CAI30416.1; -; Genomic_DNA.
DR EMBL; AJ867837; CAI30417.1; -; Genomic_DNA.
DR EMBL; AJ867838; CAI30418.1; -; Genomic_DNA.
DR AlphaFoldDB; Q705N9; -.
DR SMR; Q705N9; -.
DR GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF14; CHALCONE SYNTHASE; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003633,
KW ECO:0000313|EMBL:CAI30400.1};
KW Transferase {ECO:0000256|RuleBase:RU003633, ECO:0000313|EMBL:CAI30400.1}.
FT DOMAIN 10..232
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 243..390
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 168
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
FT NON_TER 390
FT /evidence="ECO:0000313|EMBL:CAF04430.1"
SQ SEQUENCE 390 AA; 42572 MW; F28C9490A46AA163 CRC64;
MVMAGASSLD EIRQAQRADG PAGILAIGTA NPENHVLQAE YPDYYFRITN SEHMTDLKEK
FKRSDKSTIR KRHMHLTEEF LKENPHMCAY MAPSLDTRQD IVVVEVPKLG KEAAVKAIKE
WGQPKSKITH VVFCTTSGVD MPGADYQLTK LLGLRPSVKR LMMYQQGCFA GGTVLRIAKD
LAENNRGARV LVVCSEITAV TFRGPSDTHL DSLVGQALFS DGAAALIVGS DPDTSVGEKP
IFEMVSAAQT ILPDSDGAID GHLREVGLTF HLLKDVPGLI SKNIVKSLDE AFKPLGISDW
NSLFWIAHPG GPAILDQVEI KLGLKEEKMR ATRHVLSEYG NMSSACVLFI LDEMRRKSAK
DGVATTGEGL EWGVLFGFGP GLTVETVVLH
//
