ID Q72MQ6_LEPIC Unreviewed; 327 AA.
AC Q72MQ6;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=cGMP-specific phosphodiesterase {ECO:0000313|EMBL:AAS71682.1};
GN OrderedLocusNames=LIC_13137 {ECO:0000313|EMBL:AAS71682.1};
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
OS (strain Fiocruz L1-130).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=267671 {ECO:0000313|EMBL:AAS71682.1, ECO:0000313|Proteomes:UP000007037};
RN [1] {ECO:0000313|EMBL:AAS71682.1, ECO:0000313|Proteomes:UP000007037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fiocruz L1-130 {ECO:0000313|EMBL:AAS71682.1,
RC ECO:0000313|Proteomes:UP000007037};
RX PubMed=15028702; DOI=10.1128/JB.186.7.2164-2172.2004;
RA Nascimento A.L., Ko A.I., Martins E.A., Monteiro-Vitorello C.B., Ho P.L.,
RA Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V.,
RA Oliveira M.C., Menck C.F., Leite L.C., Carrer H., Coutinho L.L.,
RA Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S., Ferro M.I.,
RA Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H.,
RA Goldman M.H., Harakava R., Jeronimo S.M., Junqueira-De-Azevedo I.L.,
RA Kimura E.T., Kuramae E.E., Lemos E.G., Lemos M.V., Marino C.L., Nunes L.R.,
RA De Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A., Siqueira W.J.,
RA Sommer P., Tsai S.M., Simpson A.J., Ferro J.A., Camargo L.E.,
RA Kitajima J.P., Setubal J.C., Van Sluys M.A.;
RT "Comparative genomics of two Leptospira interrogans serovars reveals novel
RT insights into physiology and pathogenesis.";
RL J. Bacteriol. 186:2164-2172(2004).
RN [2] {ECO:0007829|PDB:5W10}
RP X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 2-175 IN COMPLEX WITH CAMP.
RX PubMed=28601495; DOI=10.1016/j.jmb.2017.06.002;
RA da Costa Vasconcelos F.N., Maciel N.K., Favaro D.C., de Oliveira L.C.,
RA Barbosa A.S., Salinas R.K., de Souza R.F., Farah C.S., Guzzo C.R.;
RT "Structural and Enzymatic Characterization of a cAMP-Dependent Diguanylate
RT Cyclase from Pathogenic Leptospira Species.";
RL J. Mol. Biol. 429:2337-2352(2017).
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DR EMBL; AE016823; AAS71682.1; -; Genomic_DNA.
DR RefSeq; WP_000172726.1; NC_005823.1.
DR PDB; 5W10; X-ray; 2.15 A; A/B/C/D=2-175.
DR PDBsum; 5W10; -.
DR AlphaFoldDB; Q72MQ6; -.
DR SMR; Q72MQ6; -.
DR GeneID; 61143009; -.
DR KEGG; lic:LIC_13137; -.
DR HOGENOM; CLU_000445_11_24_12; -.
DR BRENDA; 2.7.7.65; 17900.
DR Proteomes; UP000007037; Chromosome I.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR PANTHER; PTHR45138:SF27; RESPONSE REGULATOR WITH GGDEF DOMAIN; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5W10};
KW Nucleotide-binding {ECO:0007829|PDB:5W10}.
FT DOMAIN 207..327
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT BINDING 46
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /evidence="ECO:0007829|PDB:5W10"
FT BINDING 47
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /evidence="ECO:0007829|PDB:5W10"
FT BINDING 48
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /evidence="ECO:0007829|PDB:5W10"
FT BINDING 65
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /evidence="ECO:0007829|PDB:5W10"
FT BINDING 83
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /evidence="ECO:0007829|PDB:5W10"
FT BINDING 84
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /evidence="ECO:0007829|PDB:5W10"
FT BINDING 106
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /evidence="ECO:0007829|PDB:5W10"
FT BINDING 117
FT /ligand="3',5'-cyclic AMP"
FT /ligand_id="ChEBI:CHEBI:58165"
FT /evidence="ECO:0007829|PDB:5W10"
SQ SEQUENCE 327 AA; 37420 MW; 1E8B1E17E6532FFD CRC64;
MTLKDSKPEL IKLYSSLGKI ITSSLEQQEV LSAVMEEVRL FFSPKNWSLM RYDENSEELF
FLIAEGIQFN HIRSIRLKSG EGIAGSVVQT KSPIFVENVK NDPRFSKKVD EKTGFETKTI
IAVPMIFRGE VHGVIELVNR FDGSSFSPED LVILQTIADF TAISLAHSDQ YEKTKILAFR
DSLTGAFNRN KLNHLKEKWS NRTMENQIAL VALLDLNGFK MINDTYGHKT GDQVLCYFAD
ILRYVIRGTD KIFRIGGDEF LILVRHENQE KILQTQNRFR ETMSVLLKKC KENDPPFNFT
WGMSIGSIQK LDELIHEADL SMYASKG
//
