ID Q72TK7_LEPIC Unreviewed; 674 AA.
AC Q72TK7;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Guanosine polyphosphate pyrophosphohydrolases/synthetases {ECO:0000313|EMBL:AAS69621.1};
GN OrderedLocusNames=LIC_11012 {ECO:0000313|EMBL:AAS69621.1};
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
OS (strain Fiocruz L1-130).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=267671 {ECO:0000313|EMBL:AAS69621.1, ECO:0000313|Proteomes:UP000007037};
RN [1] {ECO:0000313|EMBL:AAS69621.1, ECO:0000313|Proteomes:UP000007037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fiocruz L1-130 {ECO:0000313|EMBL:AAS69621.1,
RC ECO:0000313|Proteomes:UP000007037};
RX PubMed=15028702; DOI=10.1128/JB.186.7.2164-2172.2004;
RA Nascimento A.L., Ko A.I., Martins E.A., Monteiro-Vitorello C.B., Ho P.L.,
RA Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V.,
RA Oliveira M.C., Menck C.F., Leite L.C., Carrer H., Coutinho L.L.,
RA Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S., Ferro M.I.,
RA Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H.,
RA Goldman M.H., Harakava R., Jeronimo S.M., Junqueira-De-Azevedo I.L.,
RA Kimura E.T., Kuramae E.E., Lemos E.G., Lemos M.V., Marino C.L., Nunes L.R.,
RA De Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A., Siqueira W.J.,
RA Sommer P., Tsai S.M., Simpson A.J., Ferro J.A., Camargo L.E.,
RA Kitajima J.P., Setubal J.C., Van Sluys M.A.;
RT "Comparative genomics of two Leptospira interrogans serovars reveals novel
RT insights into physiology and pathogenesis.";
RL J. Bacteriol. 186:2164-2172(2004).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; AE016823; AAS69621.1; -; Genomic_DNA.
DR RefSeq; WP_000508128.1; NC_005823.1.
DR AlphaFoldDB; Q72TK7; -.
DR GeneID; 61144336; -.
DR KEGG; lic:LIC_11012; -.
DR HOGENOM; CLU_012300_3_0_12; -.
DR Proteomes; UP000007037; Chromosome I.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AAS69621.1}.
FT DOMAIN 51..150
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 391..452
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 600..674
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 674 AA; 76670 MW; 9E544FAC3FF534E3 CRC64;
MGFVKAPVTK DILLEGVCQK LGDHAYESVQ KAYDVSERAH QGQFRLSGEP YIVHPLQVGF
ILYELGLDEK VICAGLLHDV IEDTEYSRED MIRDFGEDIT DLVEGVTKIS KIKSQSKETE
AAENIRKIIV ATIKDIRVIL IKLADKTHNL RTLSFQPPEK QRRIAQETLS LYAPIAGRLG
IYKIKSELED LAFQILNPDE YQEVKKNINS KKSEREGFIE TLKIILLQRL SEIQIEADVD
GRAKHFYSIY RKMKLKEKTF NEIFDLRAIR IITNEVKDCY GVLGIVHTLW NPVPGRFKDY
IATPKTNMYQ SLHTTVIGPD GKPLEVQIRT RDMNDIAEYG IAAHWIYKEG KPSASEKNVK
VKWLELLSSW QDSALDPKEF VEELKYDLHE DEVFVFTPKG EILQLPKGAT ILDFAFRIHT
DVGLKAKGGR INGRMLPLRT ELRSGDQIEI ITDKRTKPSP IWLRIVRTPS ARQKLRSYFK
KLREENKKDL QQEAEFAAEI TLNVDVLEEL KKKPSSKPTK QIDLAAGKVI VAGLRGIPVR
LSGCCSPLPG DGIIGFVTRG RGVSIHKKGC VTAKQQEQEE SMRVITVEWD YGQSESIPVL
IEVKSKDRQG IFMEIVKSIS NTQTNIRESK ASTDQRGNLV ASFEVDVEHL DQLKEILSNL
KQIPDVYQAH RIKN
//
