ID Q73QN2_TREDE Unreviewed; 694 AA.
AC Q73QN2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Adenylate/guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:AAS10906.1};
GN OrderedLocusNames=TDE_0411 {ECO:0000313|EMBL:AAS10906.1};
OS Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS / KCTC 15104).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS10906.1, ECO:0000313|Proteomes:UP000008212};
RN [1] {ECO:0000313|EMBL:AAS10906.1, ECO:0000313|Proteomes:UP000008212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104
RC {ECO:0000313|Proteomes:UP000008212};
RX PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A., Daugherty S.C.,
RA Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.,
RA Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S.,
RA Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT "Comparison of the genome of the oral pathogen Treponema denticola with
RT other spirochete genomes.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
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DR EMBL; AE017226; AAS10906.1; -; Genomic_DNA.
DR RefSeq; NP_971025.1; NC_002967.9.
DR RefSeq; WP_002681441.1; NC_002967.9.
DR AlphaFoldDB; Q73QN2; -.
DR STRING; 243275.TDE_0411; -.
DR PaxDb; 243275-TDE_0411; -.
DR GeneID; 2740157; -.
DR KEGG; tde:TDE_0411; -.
DR PATRIC; fig|243275.7.peg.398; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG4252; Bacteria.
DR HOGENOM; CLU_000445_85_1_12; -.
DR OrthoDB; 9806704at2; -.
DR Proteomes; UP000008212; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR007890; CHASE2.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF05226; CHASE2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM01080; CHASE2; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 439..572
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 694 AA; 77345 MW; CE3800905F68D1C0 CRC64;
MKKIRRLFFI SIPVFFIVLF FIYLGVFKQA EYFFYDDRMN RTASYFSPSD EIVLVLVDQK
SLNYAASERG WTWPWPREAY ADIIDFFSGG GAKSVAFDML FTEPSSYGVA DDKKFADASR
ESGIVIQIVF FDKVQGNTKS WPDSAPKPEQ LSKNGLGPAK ELPGIFPIEE IASSARLIGN
VNSLSDSDGT IRRARLFYSW KNYKIPTLGV ASYFVGGNED EALPEELNLR FTKSIDDYLP
YSAGDILKAQ ADIRAGRESE LNPEDFEDMY VFFGLYAPGL FDICQTPVSA SYPGVGIHIT
LLDNILSGNR IVNTGFLINA LIILICIILA GLPEIFSEKI KSRTASIIVN AVSFLVFVAL
YLFIAYYLFR LGIAIPAASV LAGMALSFVA SLAVSYMVEG KQRRYLKNAF KQYLSPAVIE
QLIADPSQLK LGGERKEISI FFSDLQGFTS ISESLTPEAL TELLNDYLSD MSKIILDSGG
TIDKYEGDAI IAFWNAPARV EHHARSALEA AWACQKKLEE RRADFEKRAG GRPFKMRIGL
NTGFAIVGNM GSVSRFDYTM LGDSVNLAAR LEGLNKQFGS YTMCAEAAKK QAEESGTVLK
FRELARAAVV GKSEPVVVYE VMDEKTYNEK KALLDSFDRG LKEFYAGNFK EALNIFVQTE
EADPPSKHYA EKCKTLISQK PEGEWLGIWK ADTK
//
