ID Q73VG5_MYCPA Unreviewed; 972 AA.
AC Q73VG5;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=MmpL2 {ECO:0000313|EMBL:AAS05597.1};
GN Name=mmpL2 {ECO:0000313|EMBL:AAS05597.1};
GN OrderedLocusNames=MAP_3049c {ECO:0000313|EMBL:AAS05597.1};
OS Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS (Mycobacterium paratuberculosis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316 {ECO:0000313|EMBL:AAS05597.1, ECO:0000313|Proteomes:UP000000580};
RN [1] {ECO:0000313|EMBL:AAS05597.1, ECO:0000313|Proteomes:UP000000580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10 {ECO:0000313|Proteomes:UP000000580};
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; AE016958; AAS05597.1; -; Genomic_DNA.
DR RefSeq; WP_003874992.1; NZ_CP106873.1.
DR AlphaFoldDB; Q73VG5; -.
DR STRING; 262316.MAP_3049c; -.
DR KEGG; mpa:MAP_3049c; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_3_2_11; -.
DR Proteomes; UP000000580; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000580};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 786..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 814..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 859..892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..378
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 599..934
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT COILED 494..524
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 972 AA; 104994 MW; B31AD90AB2BEB418 CRC64;
MTTDQATRSV VAQTIRRLSV PILLVWVAVA AISNIAVPNL EDVAKAHNVS LNTPAAPSFQ
AMQHIGKVFH EYDSDSAAMI VLEGDKPLGD DAHRFYDALV GKLEHDTKHV EHVQNFWGDP
LTAAGSQSKD GKAAYVQVYL AGNQGDALAN ESVDAIRNIV EHTPPPPGVK AYVTGAAPLV
TDQFEVGSKG IFKVTVITVL VILAMLLWVY RSVTAVFVLV TVIVEMAAAR GIVAFLGSVG
LIGLSTYATN LLTLLVIAAG TDYAIFFVGR YHEARHEGQD RETAYYTMYR GTTHVVLGSG
LTVAGAVLCL RFTRLNYFQS LGIPAAIGIG VALAAALSLT PAVITVGSLF GLFDPKRQMA
TRGWRRIGTA IVRWPGPILV VATGVALVGL LALPGYRTNY DARPYMPASA PANTGYTAAE
RHFSQARLNP ELLMIETDHD MRNPADMINL ERVAKAIAHL PGIAQVQSMT RPLGTPIEHT
SLAFQISAGS IGSIENLQYQ KERAEDLLKQ ADNLKDTIGI LNQQYALQKQ LAASTHDETQ
SFHDTIAIIN DLRDKIANFD DFFRPVRSYF YWEKHCFDIP ACFAFRSVFD ALDGIDELSA
QFEKLTASLD KLDAGQQKLV TLLPPQIADQ EKNLALTLSN YATNLGINAQ TRANTDTATA
LGQAYDAAKN DDSFYLPPEA FTNPEFKRGL KLFLSPDGKA ARMIISHEGD PATPEGISHI
EPIRNAAKQA VKNTPLGDSN IYLAGTAATY KDIAEGAKYD LLIAGIAALS LILLIMVLIT
RSLVAAIVIV GTVALSLGAS FGLSVLVWQD ILGIKLYWIC LALSVIILLA VGSDYNLLLI
SRFREEIHAG LNTGIIRSMA GSGAVVTSAG LVFAFTMASF VSASLLVLGQ IGTTIALGLL
FDTLIVRSFM TPSVAALLGR WFWWPQRVRP RPASTMLRPY GPRPAVRQLL LWEDGDPAVA
PETPSAARHS RG
//
